甲烷-硝酸(1:1) | 97659-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 甲烷-硝酸(1:1)
• 英文名称: 2-ethyl-6-hydroxy-isonicotinic acid
• 英文别名: 2-Aethyl-6-hydroxy-isonicotinsaeure；6-Ethyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid；2-ethyl-6-oxo-1H-pyridine-4-carboxylic acid
• CAS: 97659-42-2
• 化学式: C₈H₉NO₃
• 分子量: 167.164
• InChiKey: QTGMQKBCDNYHSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲烷-硝酸(1:1) 在 五氯化磷 、 钯 、 溶剂黄146 、 三氯氧磷 作用下， 生成 2-乙基-(9ci)-4-吡啶羧酸
  参考文献：
  名称：

  Associations Between Egg Production and Clutch Length in Four Selected Lines of Chickens

  摘要：

  The use of partial records to measure egg production of pedigree breeders has numerous advantages including reduced labor and generation interval. Maintaining egg production in an era where emphasis in breeding programs involves yield and feed conversion presents a challenge to primary breeders. Because breeders obtain individual egg production records, interest in the possibility of using the association of various measures of clutch length with intensity of egg production has been renewed. The correlation of maximum clutch length (prime sequence) throughout lay and during the first 10, 15, and 30 d of lay with percentage hen-day ovulations and normal eggs in four lines (two White Leghorn and two White Plymouth Rock) of chickens during each of 2 yr was measured. Although the rankings of the lines were generally consistent both years for all traits measured, correlations among the sequence lengths with percentage hen-day ovulations and normal eggs were line specific. Thus, poultry breeders would have to determine which of these measures is most appropriate for inclusion with other measures of egg production for each of their specific lines.

  DOI：

  10.1093/japr/11.3.304
• 作为产物：
  描述：

  2,4-二氧代己酸乙酯 在 哌啶 、 盐酸 、 乙醇 作用下， 生成 甲烷-硝酸(1:1)
  参考文献：
  名称：

  Associations Between Egg Production and Clutch Length in Four Selected Lines of Chickens

  摘要：

  The use of partial records to measure egg production of pedigree breeders has numerous advantages including reduced labor and generation interval. Maintaining egg production in an era where emphasis in breeding programs involves yield and feed conversion presents a challenge to primary breeders. Because breeders obtain individual egg production records, interest in the possibility of using the association of various measures of clutch length with intensity of egg production has been renewed. The correlation of maximum clutch length (prime sequence) throughout lay and during the first 10, 15, and 30 d of lay with percentage hen-day ovulations and normal eggs in four lines (two White Leghorn and two White Plymouth Rock) of chickens during each of 2 yr was measured. Although the rankings of the lines were generally consistent both years for all traits measured, correlations among the sequence lengths with percentage hen-day ovulations and normal eggs were line specific. Thus, poultry breeders would have to determine which of these measures is most appropriate for inclusion with other measures of egg production for each of their specific lines.

  DOI：

  10.1093/japr/11.3.304

文献信息

• Chemotherapie der experimentellen Tuberkulose III. Derivate des 2-Methyl-isonicotinsäurehydrazids
  作者：O. Isler、H. Gutmann、O. Straub、B. Fust、E. Böhni、A. Studer

  DOI：10.1002/hlca.19550380425

  日期：——

  Some fifty-two derivatives of 2-methylisonicotinic acid hydrazide were synthesized and tested for their antitubercular action. The derivatives were prepared by reaction of 2-methylisonicotinic acid hydrazide with aldehydes, ketones, and carboxylic acid chlorides, by condensation of 2-methylisonicotinic acid chloride with dialkylated hydrazines, and by hydrogenation of 2-methylisonicotinyl hydrazones

  合成了约52个2-甲基异烟酸酰肼衍生物，并测试了它们的抗结核作用。通过2-甲基异烟酰胺酰肼与醛，酮和羧酸氯化物的反应，通过2-甲基异烟酰胺酰氯与二烷基化肼的缩合，以及2-甲基异烟碱酰肼的氢化来制备衍生物。
• Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof
  申请人：MAILLIET Patrick

  公开号：US20080153837A1

  公开（公告）日：2008-06-26

  This invention relates to derivatives of 4-(benzimidazol-2-yl)fluorene and 4-(azabenzimidazol-2-yl)fluorene, to pharmaceutical compositions comprising such derivatives, and to methods of treatment of disorders related to Hsp90 protein activity, comprising administering such derivatives.

  这项发明涉及4-(苯并咪唑-2-基)芴和4-(氮杂苯并咪唑-2-基)芴的衍生物，涉及包含这些衍生物的药物组合物，以及涉及治疗与Hsp90蛋白活性相关的疾病的方法，包括给予这些衍生物。
• Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
  作者：Andrey Tolmachev、Andrey V. Bogolubsky、Sergey E. Pipko、Alexander V. Grishchenko、Dmytro V. Ushakov、Anton V. Zhemera、Oleksandr O. Viniychuk、Anzhelika I. Konovets、Olga A. Zaporozhets、Pavel K. Mykhailiuk、Yurii S. Moroz

  DOI：10.1021/acscombsci.6b00103

  日期：2016.10.10

  One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from carboxylic acids and nitriles was optimized to parallel chemistry. The method was validated on a 141 member library; the desired products were recovered with a high success rate and in moderate yields. Practical application of the approach was demonstrated in the synthesis of bioactive compound pifexole and agonists of free fatty acid receptor

  优化了从羧酸和腈的一锅法合成3,5-二取代的1,2,4-恶二唑的平行化学反应。该方法已在141个成员库中得到验证；以高成功率和中等收率回收了所需的产品。该方法在生物活性化合物吡非索和游离脂肪酸受体1激动剂的合成中得到了实际应用。在此基础上，列举了4 948 100种可合成的药物样3,5-二取代1,2,4-恶二唑类化合物。方法和可用的经过验证的试剂。
• [EN] SULFOXIMINE SUBSTITUTED 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES AND THEIR USE AS CDK9 KINASE INHIBITORS<br/>[FR] DÉRIVÉS 5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE SUBSTITUÉS PAR UN GROUPE SULFOXIMINE ET LEUR UTILISATION COMME INHIBITEURS DE LA CDK9 KINASE
  申请人：BAYER PHARMA AG

  公开号：WO2015001021A1

  公开（公告）日：2015-01-08

  The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper- proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

  本发明涉及一种含有亚砜基团的5-氟-N-(吡啶-2-基)吡啶-2-胺衍生物，其通式(I)如所述和定义的那样，并且涉及其制备方法，以及它们用于治疗和/或预防疾病，特别是增殖过度性疾病和/或病毒感染性疾病和/或心血管疾病的方法。本发明还涉及用于制备通式(I)所述化合物的中间体化合物。
• Organic Compounds
  申请人：Ehara Takeru

  公开号：US20090192148A1

  公开（公告）日：2009-07-30

  The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The compounds have the formula I′ wherein R1, R2, T, R3 and R4 areas defined in the specification.

  本发明涉及3,5-取代哌啶化合物，这些化合物用于诊断和治疗温血动物，特别是用于治疗依赖肾素活性的疾病（=失调）；该类化合物用于制备治疗依赖肾素活性疾病的制剂；该类化合物用于治疗依赖肾素活性的疾病；包括3,5-取代哌啶化合物的制药配方和/或包括给予3,5-取代哌啶化合物的治疗方法，以及制造3,5-取代哌啶化合物的新型中间体和部分合成步骤。该化合物的式子为I'，其中R1、R2、T、R3和R4在规范中有定义。