(4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropyl]carbamate | 391624-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropyl]carbamate
• CAS: 391624-40-1
• 化学式: C₃₁H₂₇N₃O₆
• 分子量: 537.572
• InChiKey: UJHQWBRJIDQQEA-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-fluorenylmethoxycarbonyl-N'-nitrophenoxycarbonyl-diaminoethane 、 (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylpentyl]carbamate 、 (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropyl]carbamate 以29 mg的产率得到N-[2-[2-[[(2S)-1-[[(2S)-1-(carbamoylamino)-4-methylpentan-2-yl]carbamoylamino]-3-phenylpropan-2-yl]carbamoylamino]ethylcarbamoylamino]ethyl]acetamide
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy

  摘要：

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

  DOI：

  10.1021/jo010656q
• 作为产物：
  描述：

  (s)-N-FMOC基苯丙氨醇 在 10percent Pd/C 三(2-氯乙基)胺 、 氢气 、 N,N-二异丙基乙胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 苯 为溶剂， 生成 (4-nitrophenyl) N-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropyl]carbamate
  参考文献：
  名称：

  Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy

  摘要：

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).

  DOI：

  10.1021/jo010656q

文献信息

• Solid-Phase Synthesis of Oligourea Peptidomimetics Employing the Fmoc Protection Strategy
  作者：Astrid Boeijen、Jeroen van Ameijde、Rob M. J. Liskamp

  DOI：10.1021/jo010656q

  日期：2001.12.1

  A solid-phase-Fmoc-based-synthesis strategy is described for oligourea peptidomimetics as well as a convenient general synthesis approach for the preparation of the required building blocks 5a-j and 5k. These are suitable for use in peptide or robot synthesizers, which is illustrated by the synthesis of oligourea peptidomimetics of part of Leu-enkephalin (10) and a neurotensin derivative (17).