leucyl-glutamine | 38062-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: leucyl-glutamine
• 英文别名: N²-leucyl-glutamine；5-amino-2-[(2-azaniumyl-4-methylpentanoyl)amino]-5-oxopentanoate
• CAS: 38062-69-0；38062-70-3
• 化学式: C₁₁H₂₁N₃O₄
• mdl: MFCD01081471
• 分子量: 259.305
• InChiKey: JYOAXOMPIXKMKK-UHFFFAOYSA-N

物化性质

• 熔点：
  235-236 °C
• 沸点：
  591.3±50.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.727
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N²-(2-bromo-4-methyl-valeryl)-glutamine 在 氨 、 水 作用下， 生成 leucyl-glutamine
  参考文献：
  名称：

  Thierfelder; v. Cramm, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1919, vol. 105, p. 80

  摘要：

  DOI：

文献信息

• Compositions to improve tic disorders
  申请人：Ozeki Makoto

  公开号：US20060217321A1

  公开（公告）日：2006-09-28

  Tic disorders can be improved by administering theanine, an amino acid that crosses the blood-brain barrier, or a dipeptide consisting of theanine and a different amino acid. In addition, these compositions can be added to foods and drinks or pharmaceuticals.

  滴状障碍可以通过给予茶氨酸改善，这是一种可以穿过血脑屏障的氨基酸，或者是由茶氨酸和另一种氨基酸组成的二肽。此外，这些组合物可以添加到食品和饮料或药品中。
• Glutamine or glutamine-containing dipeptide in a specific dosage for the treatment of inflammation
  申请人：Biotempt B.V.

  公开号：EP2106791A1

  公开（公告）日：2009-10-07

  Described are methods of treating or preventing an inflammation by administering to a patient in need thereof a pharmacologic dose of glutamine or a glutamine-containing dipeptide in a pharmaceutically acceptable carrier, wherein said dose is selected from a range of 0.09 to 90mg glutamine per kg bodyweight of the patient.

  描述了治疗或预防炎症的方法，给有需要的患者施用药理剂量的谷氨酰胺或含谷氨酰胺二肽的药学上可接受的载体，其中所述剂量选自患者每公斤体重 0.09 至 90 毫克谷氨酰胺的范围。
• Compositions and methods for improving skin health and for the treatment and prevention of diseases, disorders and conditions associated with pathogenic microbes
  申请人：DermBiont, Inc.

  公开号：US11040077B2

  公开（公告）日：2021-06-22

  Disclosed herein are compositions and methods for using human-derived Janthinobacterium lividum. Compositions improve skin health. Methods may include applying human-derived Janthinobacterium lividum over a host or host area, such as skin or mucosa, to minimize the presence of one or more microbes, maximize therapeutic effects, and/or improve health. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-derived Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic to maximize growth and/or metabolites. Compositions and methods may include human-derived Janthinobacterium lividum metabolites, such as violacein, prodigiosin, indole-3-carboxaldehyde, and lantibiotics, and/or other Postbiotics.

  本文公开了使用源自人类的 Lividum Janthinobacterium 的组合物和方法。组合物可改善皮肤健康。方法可包括在宿主或宿主区域（如皮肤或粘膜）上施用源于人的生发的Lividum Janthinobacterium，以最大限度地减少一种或多种微生物的存在，最大限度地提高治疗效果，和/或改善健康状况。减少病原微生物的方法可包括向表面施用一种组合物，该组合物包括来源于人类的Janthinobacterium lividum和一种可接受的载体。组合物和方法可包括益生元，以最大限度地提高生长和/或代谢物。组合物和方法可包括来源于人的猪蓝细菌代谢物，如violacein、prodigiosin、吲哚-3-甲醛、兰特益生菌和/或其他后益生菌。
• Glutamine for use in treating injury
  申请人：Wischmeyer Paul

  公开号：US20050059610A1

  公开（公告）日：2005-03-17

  A method of treating a problem relating to tissue metabolism by administering to a patient in need a single dose of glutamine in a pharmaceutically acceptable carrier. Also provided is glutamine for the treatment of an injury relating to tissue metabolism and for preventing cardiac cell damage. A therapeutic composition for treating and preventing cellular metabolic injury, preventing cardiac cell damage, and increasing heat shock protein expression where in the therapeutic includes a single dose of glutamine in a pharmaceutically acceptable carrier is also provided. A method of increasing the expression of heat shock proteins by administering a single dose of glutamine in a pharmaceutically acceptable carrier to a location in need is further provided.

  一种治疗与组织代谢有关的问题的方法，通过向有需要的患者施用单剂量谷氨酰胺，并将其置于药学上可接受的载体中。还提供了用于治疗与组织代谢有关的损伤和预防心脏细胞损伤的谷氨酰胺。还提供了一种用于治疗和预防细胞代谢损伤、预防心脏细胞损伤和增加热休克蛋白表达的治疗组合物，其中治疗物包括药学上可接受的载体中的单剂量谷氨酰胺。此外，还提供了一种通过向有需要的部位施用单剂量谷氨酰胺在药学上可接受的载体中来增加热休克蛋白表达的方法。
• GLUTAMINE FOR USE IN TREATING INJURY
  申请人：University of Colorado

  公开号：EP1663283A1

  公开（公告）日：2006-06-07