B | 40221-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: B
• 英文别名: 1-N,3-N-bis(2-aminoethyl)benzene-1,3-dicarboxamide
• CAS: 40221-64-5
• 化学式: C₁₂H₁₈N₄O₂
• 分子量: 250.301
• InChiKey: MAGHRAPVPMMAHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  110
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-(quinolin-8-yloxy)acetate 、 B 以 乙腈 为溶剂， 以26.8%的产率得到1-N,3-N-bis[2-[(2-quinolin-8-yloxyacetyl)amino]ethyl]benzene-1,3-dicarboxamide
  参考文献：
  名称：

  Cu(II) complex of an abiotic receptor as highly selective fluorescent sensor for acetate

  摘要：

  A copper complex having quinoline moiety as fluorophore has been synthesized. The anion recognition behavior of the receptor and its copper complex has been studied in acetonitrile and in acetonitrile: H2O (95:5 v/v). The copper complex shows high selectivity toward acetate over other anions studied such as F-, Cl-, Br-, I-, OAc-, DL-malate, L-mandelate, benzoate, isophthalate, H2PO4-, NO3- and HSO4-. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.021
• 作为产物：
  描述：

  间苯二甲酸二甲酯 、 乙二胺 以 乙腈 为溶剂， 反应 5.0h， 以31.3%的产率得到B
  参考文献：
  名称：

  Cu(II) complex of an abiotic receptor as highly selective fluorescent sensor for acetate

  摘要：

  A copper complex having quinoline moiety as fluorophore has been synthesized. The anion recognition behavior of the receptor and its copper complex has been studied in acetonitrile and in acetonitrile: H2O (95:5 v/v). The copper complex shows high selectivity toward acetate over other anions studied such as F-, Cl-, Br-, I-, OAc-, DL-malate, L-mandelate, benzoate, isophthalate, H2PO4-, NO3- and HSO4-. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.021

文献信息

• Dimeric and trimeric nucleic acid dyes, and associated systems and methods
  申请人：Mao Fei

  公开号：US20060211028A1

  公开（公告）日：2006-09-21

  Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

  本文提供了二聚和三聚核酸染料，以及相关系统和方法。这样的染料可以形成类似发夹的结构，通过按需释放机制染色核酸。例如，这样的染料在缺乏核酸时具有低背景荧光，在与核酸结合后具有高荧光。本文提供的染料可以在各种应用中发挥作用，例如在实时PCR中进行DNA定量。
• Methods of using dyes in association with nucleic acid staining or detection and associated technology
  申请人：Mao Fei

  公开号：US20060211029A1

  公开（公告）日：2006-09-21

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供使用染料和相关技术的方法。染料，例如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。在这样的应用中，可以使用这样的染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐。二聚体染料，例如能够形成类似发夹结构的二聚体染料，可通过按需释放机制用于染色和/或检测核酸。在没有核酸的情况下具有低背景荧光，与核酸结合后具有高荧光的二聚体染料，可用于染色和/或检测核酸。
• METHODS OF USING DYES IN ASSOCIATION WITH NUCLEIC ACID STAINING OR DETECTION AND ASSOCIATED TECHNOLOGY
  申请人：Mao Fei

  公开号：US20100009454A1

  公开（公告）日：2010-01-14

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供了使用染料及相关技术的方法。染料，如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。这种染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐可以用于这种应用。一种二聚体染料，如能够形成类似发夹结构的二聚体染料，可通过按需释放机制用于染色和/或检测核酸。一种二聚体染料，在没有核酸存在时具有低背景荧光，与核酸结合后在核酸存在时具有高荧光，可用于染色和/或检测核酸。
• Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology
  申请人：Biotium, Inc.

  公开号：US20140073058A1

  公开（公告）日：2014-03-13

  Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

  提供了使用染料及相关技术的方法。染料，如单体染料或二聚体染料，可用于核酸凝胶染色应用和/或核酸检测应用。这样的染料和包含与强酸相关联的阴离子和与强碱相关联的阳离子的盐可以在这种应用中使用。二聚体染料，如能够形成类似发夹状结构的二聚体染料，可以通过按需释放机制用于染色和/或检测核酸。在没有核酸存在时具有低背景荧光而在与核酸结合后具有高荧光的二聚体染料，可用于染色和/或检测核酸。
• COMPOSITIONS AND METHODS COMPRISING A BIOCIDAL POLYAMINE
  申请人：Curza Global, LLC

  公开号：US20150038512A1

  公开（公告）日：2015-02-05

  Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.

  本发明涉及一种包含聚胺化合物的化合物、组合物和方法，可用于杀死、分散、治疗或减少生物膜，或抑制或大幅预防生物膜的形成。在某些方面，本发明涉及包含聚胺化合物的化合物、组合物和方法，其具有针对能够形成生物膜的各种细菌菌株的抗微生物或分散活性。