N-L-prolyl-L-leucine | 52899-07-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-L-prolyl-L-leucine
• 英文别名: N-L-Prolyl-L-leucin；4-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]pentanoic acid
• CAS: 52899-07-7
• 化学式: C₁₁H₂₀N₂O₃
• 分子量: 228.291
• InChiKey: ZKQOUHVVXABNDG-IENPIDJESA-N

物化性质

• 熔点：
  253-255℃
• 沸点：
  457.5±45.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

反应信息

• 作为产物：
  描述：

  N-苄氧羰基-L-脯氨酸 在 sodium hydroxide 、 乙醚 、 三氯化磷 作用下， 生成 N-L-prolyl-L-leucine
  参考文献：
  名称：

  Abderhalden; Nienburg, Fermentforschung, 1933, vol. 13, p. 573,594

  摘要：

  DOI：

文献信息

• ANTIBODY-PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP3690038A1

  公开（公告）日：2020-08-05

  The present invention provides a novel antibody-pyrrolodiazepine derivative and a novel antibody-pyrrolodiazepine derivative conjugate using the same, and a novel CLDN6 and/or CLDN9 antibody.

  本发明提供了一种新型抗体-吡咯并二氮杂卓衍生物和使用该衍生物的新型抗体-吡咯并二氮杂卓衍生物共轭物，以及一种新型 CLDN6 和/或 CLDN9 抗体。
• Complex Human Gut Microbiome Cultured In An Anaerobic Human Gut-On-A-Chip
  申请人：President and Fellows of Harvard College

  公开号：US20210079356A1

  公开（公告）日：2021-03-18

  A microfluidic device is directed to sustaining a complex microbial community in direct and indirect contact with living human intestinal cells in vitro. The device includes a first microchannel having cultured cells of a human intestinal epithelium and microbiota, the first microchannel further having a first level of oxygen. The device further includes a second microchannel having cultured cells of a vascular endothelium, the second microchannel further having a second level of oxygen. The device also includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane being composed of an oxygen-permeable material or further having pores via which oxygen flows between the first microchannel and the second microchannel to form a physiologically-relevant oxygen gradient.