萝巴新 | 4373-34-6

• 物质功能分类: 原料药 - 神经系统用药 - 脑代谢调节药
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 育亨宾生物碱
• 中文名称: 萝巴新
• 中文别名: 盐酸阿吗碱
• 英文名称: (-)-Ajmalicine hydrochloride
• 英文别名: yohimbine hydrochloride；(16E,19S)-17,19-epoxy-coryn-16-ene-16-carboxylic acid methyl ester; hydrochloride；(16E,19S)-17,19-Epoxy-coryn-16-en-16-carbonsaeure-methylester; Hydrochlorid；hydron;methyl (1S,15R,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate;chloride
• CAS: 4373-34-6
• 化学式: C₂₁H₂₄N₂O₃*ClH
• 分子量: 388.894
• InChiKey: YWPZOTNKHMBWPD-QAWKRFFXSA-N

物化性质

• 熔点：
  275-300 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  54.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26,S36
• 危险类别码：
  R22,R36/37/38
• WGK Germany：
  3

制备方法与用途

类别：有毒物品

毒性分级：高毒

急性毒性：

• 口服-小鼠 LD50: 50 毫克/公斤
• 静脉-小鼠 LD50: 56 毫克/公斤

可燃性危险特性：可燃；燃烧时释放有毒氮氧化物和氯化氢烟雾

储运特性：应存放在库房中通风、低温且干燥的环境中，并与氧化剂及食品添加剂分开存放

灭火剂：使用泡沫、砂土或水进行灭火。

反应信息

• 作为反应物：
  描述：

  萝巴新 在 硫酸氢铵 、 potassium dihydrogenphosphate 、 sodium dihydrogenphosphate 、 葡萄糖 、 corn steep liquor 、 calcium carbonate 作用下， 以 水 为溶剂， 反应 144.0h， 以92%的产率得到10-hydroxyajmalicine
  参考文献：
  名称：

  Microbial hydroxylation of heteroyohimbine alkaloids

  摘要：

  DOI：

  10.1021/jo00169a049

文献信息

• METHODS AND COMPOSITIONS FOR TREATING INFECTION
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20150238473A1

  公开（公告）日：2015-08-27

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• IDENTIFICATION OF STRUCTURALLY SIMILAR SMALL MOLECULES THAT ENHANCE THERAPEUTIC EXON SKIPPING
  申请人：The Regents of the University of California

  公开号：US20160257952A1

  公开（公告）日：2016-09-08

  This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of a compound such as, for example, Perphenazine, Flupentixol DiHCl, Zuclopenthixol or Corynanthine HCl, or a compound which shares a similar 2-D structure and activity level with one of these compounds, or a pharmaceutically acceptable salt, hydrate, solvate, or isomer of the compound, and, optionally, with an antisense oligonucleotide that is specific for a splicing sequence in the pre-mRNA Methods for treating Duchenne muscular dystrophy (DMD) are disclosed.

  本发明涉及一种增强感兴趣的前mRNA的外显子跳跃的方法，包括将前mRNA与有效量的化合物接触，例如Perphenazine、Flupentixol DiHCl、Zuclopenthixol或Corynanthine HCl，或具有类似2-D结构和活性水平的化合物，或化合物的药学上可接受的盐，水合物，溶剂化物或异构体，以及选择性针对前mRNA中剪接序列的反义寡核苷酸（如果需要）。还公开了治疗杜氏肌肉萎缩症（DMD）的方法。
• Methods and compositions for treating infection
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10004701B2

  公开（公告）日：2018-06-26

  Provided herein are compositions and methods for treating or preventing infection.

  本文提供了用于治疗或预防感染的组合物和方法。
• Means and Methods to Enhance the Production of Vinblastine and Vincristine in Catharanthus Roseus
  申请人：Goossens Alain

  公开号：US20090165167A1

  公开（公告）日：2009-06-25

  The present invention relates to the field of plant secondary metabolites, particularly terpenoid indole alkaloids. More particularly the present invention relates to the production of the anti-cancer metabolites vincristine and vinblastine. The invention provides novel polynucleotide sequences derived from Catharanthus roseus and the use of said polynucleotide sequences to stimulate the production of vinblastine and/or vincristine in plants of Catharanthus roseus and plant cell lines derived thereof. The invention further relates to recombinant plants, plant cells, tissue and organ cultures obtainable by the process of the invention.
• METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE
  申请人：Wu Sean

  公开号：US20130023488A1

  公开（公告）日：2013-01-24

  Compounds and compositions for reducing intracellular lipid accumulation in a cell are described herein. These compounds are useful for the treatment and prevention of lipid/glycogen disorders, as well as for the treatment and prevention of obesity. A high throughput screen for identifying compounds that reduce intracellular lipid accumulation in cells is also provided.