盐酸美托舍酯

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 育亨宾生物碱
• 中文名称: 盐酸美托舍酯
• 中文别名: 美托舍酯盐酸盐；甲基11,17alpha,18alpha-三甲氧基-3beta,20alpha-育亨宾-16beta-羧酸酯单盐酸盐
• 英文名称: hydron;methyl (1R,15S,17S,18R,19S,20S)-6,17,18-trimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;chloride
• 化学式: C24H33ClN2O5
• 分子量: 465.0
• InChiKey: RVUCXCLULXWKIQ-PKNINNMNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  73
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS
  申请人：Illustris Pharmaceuticals, Inc.

  公开号：EP3442488A1

  公开（公告）日：2019-02-20
• METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY
  申请人：Illustris Pharmaceuticals, Inc.

  公开号：EP3694489A2

  公开（公告）日：2020-08-19
• [EN] COMPOSITIONS FOR TOPICAL APPLICATION OF COMPOUNDS<br/>[FR] COMPOSITIONS POUR L'APPLICATION TOPIQUE DE COMPOSÉS
  申请人：ILLUSTRIS PHARMACEUTICALS INC

  公开号：WO2017180788A1

  公开（公告）日：2017-10-19

  Compositions for transdermal delivery of an active agent and methods for using such compositions are described herein.
• [EN] METHODS AND COMPOSITIONS FOR TOPICAL DELIVERY<br/>[FR] PROCÉDÉS ET COMPOSITIONS À ADMINISTRATION TOPIQUE
  申请人：ILLUSTRIS PHARMACEUTICALS INC

  公开号：WO2019075263A2

  公开（公告）日：2019-04-18

  Compositions for topical delivery of an active agent and methods for using such compositions are described herein. Compositions include one or more active agents and about 0.001 wt. % to about 10 wt. % of a extracellular matrix component having average molecular weight of about 2,000 daltons to about 20,000 daltons. The extracellular components include hyaluronic acid, collagen, fibronectin, elastin, lectin, and fragments thereof and combinations thereof.