2-dimethylamino-1H-pyrimidine-4,6-dione | 117290-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-dimethylamino-1H-pyrimidine-4,6-dione
• 英文别名: 2-Dimethylamino-1H-pyrimidin-4,6-dion；2-(Dimethylamino)-1,5-dihydropyrimidine-4,6-dione；2-(dimethylamino)-1H-pyrimidine-4,6-dione
• CAS: 117290-56-9
• 化学式: C₆H₉N₃O₂
• 分子量: 155.156
• InChiKey: FKXULIAFNPWPGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.05
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  61.77
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-dimethylamino-1H-pyrimidine-4,6-dione 在 乙醇 、 氨 、 三氯氧磷 作用下， 生成 6-氯-N2,N2-二甲基-2,4-嘧啶二胺
  参考文献：
  名称：

  Nutritional Parameters, Body Composition, and Progression of Disability in Older Disabled Residents Living in Nursing Homes

  摘要：

  Background. The evaluation of nutritional status is one of the primary components of multidimensional geriatric assessment. We investigated the relationship between some markers of malnutrition and the modification,ns in functional status in a sample of older disabled residents living in nursing homes.Methods. Ninety-eight subjects who were independent in at least two activities of daily living (ADLs) were enrolled in a 2-year longitudinal study. Anthropometric. nutritional, and metabolic parameters. as well us body composition. were measured at baseline and after 2 years.Results. Deteriorating functional status (greater than or equal to2 additional lost ADLs) was associated with baseline albumin levels (Tertile 3 vs Tertile 1: odds ratio [OR] 0.16, 95% confidence interval [CI] 0.01-0.67) and subscapular skinfold thick,less (Tertile 3 vs Tertile 1:OR 0.06, 95% CI 0.006-0.50). After multivariate adjustment. the OR for increasing disability was >4 in subjects with decreasing body cell mass (BCM), compared with subjects with a stable BCM. The degree of BCM reduction was strongly related to the number of additional ADLs lost at follow-up (test for trend. p = .003).Conclusions. In a sample of older disabled nursing home residents, signs of malnutrition seem to predict further worsening in functional status. Furthermore. BCM declines proportionally to the loss in ADLs. suggesting the existence of a strong relationship between BCM loss and the progressive deterioration of functional status.

  DOI：

  10.1093/gerona/56.4.m212
• 作为产物：
  描述：

  N,N-二甲基胍 、 丙二酸二乙酯 生成 2-dimethylamino-1H-pyrimidine-4,6-dione
  参考文献：
  名称：

  Nutritional Parameters, Body Composition, and Progression of Disability in Older Disabled Residents Living in Nursing Homes

  摘要：

  Background. The evaluation of nutritional status is one of the primary components of multidimensional geriatric assessment. We investigated the relationship between some markers of malnutrition and the modification,ns in functional status in a sample of older disabled residents living in nursing homes.Methods. Ninety-eight subjects who were independent in at least two activities of daily living (ADLs) were enrolled in a 2-year longitudinal study. Anthropometric. nutritional, and metabolic parameters. as well us body composition. were measured at baseline and after 2 years.Results. Deteriorating functional status (greater than or equal to2 additional lost ADLs) was associated with baseline albumin levels (Tertile 3 vs Tertile 1: odds ratio [OR] 0.16, 95% confidence interval [CI] 0.01-0.67) and subscapular skinfold thick,less (Tertile 3 vs Tertile 1:OR 0.06, 95% CI 0.006-0.50). After multivariate adjustment. the OR for increasing disability was >4 in subjects with decreasing body cell mass (BCM), compared with subjects with a stable BCM. The degree of BCM reduction was strongly related to the number of additional ADLs lost at follow-up (test for trend. p = .003).Conclusions. In a sample of older disabled nursing home residents, signs of malnutrition seem to predict further worsening in functional status. Furthermore. BCM declines proportionally to the loss in ADLs. suggesting the existence of a strong relationship between BCM loss and the progressive deterioration of functional status.

  DOI：

  10.1093/gerona/56.4.m212

文献信息

• Boon, Journal of the Chemical Society, 1957, p. 2151
  作者：Boon

  DOI：——

  日期：——
• Nakashima, Kenichiro; Ando, Taiji; Nakamura, Kyoko, Chemical and pharmaceutical bulletin, 1983, vol. 31, # 7, p. 2523 - 2525
  作者：Nakashima, Kenichiro、Ando, Taiji、Nakamura, Kyoko、Akiyama, Shuzo

  DOI：——

  日期：——