Regioselective Cp*Ir(III)-Catalyzed Allylic C–H Sulfamidation of Allylbenzene Derivatives
作者:Amaan M. Kazerouni、Taylor A. F. Nelson、Steven W. Chen、Kimberly R. Sharp、Simon B. Blakey
DOI:10.1021/acs.joc.9b01816
日期:2019.10.18
In this study we report the development of the regioselective Cp*Ir(III)-catalyzed allylic C-H sulfamidation of allylbenzene derivatives, using azides as the nitrogen source. The reaction putatively proceeds through a Cp*Ir(III)-π-allyl intermediate and demonstrates exclusive regioselectivity for the branched position of the π-allyl. The reaction performs well on electron-rich and electron-deficient
A widely used Lewis acid BF3·Et2O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence