9,9'-diacetyl-9,9'-bifluorenyl | 62731-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9,9'-diacetyl-9,9'-bifluorenyl
• 英文别名: 1-[9-(9-Acetylfluoren-9-yl)fluoren-9-yl]ethanone
• CAS: 62731-54-8
• 化学式: C₃₀H₂₂O₂
• 分子量: 414.503
• InChiKey: AKKJKHHCNWBKBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9,9'-diacetyl-9,9'-bifluorenyl 在 sodium ethanolate 作用下， 以 苯 为溶剂， 生成 3-Methyl-4,5-bis-(2,2'-biphenylylen)-2-cyclopenten-1-on
  参考文献：
  名称：

  一些9-酰基芴的脱酰化与合成

  摘要：

  研究了取代的 9-乙酰基-、9-丙酰基-、9-苯甲酰基-芴和 9-芴基 9-甲基-9-芴基酮的脱酰反应；9-乙酰芴上的9-氢原子的取代增强了脱酰反应的反应性。9-乙酰芴与硝酸乙酯反应得到9-乙酰硝基芴。

  DOI：

  10.1246/bcsj.50.258
• 作为产物：
  描述：

  9-acetylfluorene 在 氯化亚砜 、 铜 作用下， 生成 9,9'-diacetyl-9,9'-bifluorenyl
  参考文献：
  名称：

  Greenhow et al., Journal of the Chemical Society, 1954, p. 3116,3119

  摘要：

  DOI：

文献信息

• KIMURA TAKAO; MINABE MASAHIRO; TSUBOTA MOTOHIRO; SUZUKI KAZUO, BULL. CHEM. SOC. JAP., 1977, 50, NO 1, 258-260,
  作者：KIMURA TAKAO、 MINABE MASAHIRO、 TSUBOTA MOTOHIRO、 SUZUKI KAZUO

  DOI：——

  日期：——
• SMALL MOLECULES THAT INDUCE INTRINSIC PATHWAYS APOPTOSIS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20170105963A1

  公开（公告）日：2017-04-20

  Apoptosis is generally believed to be a process that requires several hours, in contrast to non-programmed forms of cell death that can occur in minutes. Our findings challenge the time-consuming nature of apoptosis. We describe herein the discovery and characterization of a small molecule, named Raptinal, which initiates intrinsic pathway caspase-dependent apoptosis within minutes, in multiple different cell lines. Comparison to a mechanistically diverse panel of apoptotic stimuli reveals Raptinal-induced apoptosis proceeds with unparalleled speed. The rapid phenotype enabled identification of the critical roles of mitochondrial voltage-dependent anion channel function, mitochondrial membrane potential/coupled respiration, and mitochondrial complex I, III and IV function for apoptosis induction. Use of Raptinal in whole organisms demonstrates its utility to study apoptosis in vivo for a variety of applications. Overall, rapid inducers of apoptosis are powerful tools that will be used in a variety of settings to generate further insight into the apoptotic machinery.
• US9682060B2
  申请人：——

  公开号：US9682060B2

  公开（公告）日：2017-06-20
• Greenhow et al., Journal of the Chemical Society, 1954, p. 3116,3119
  作者：Greenhow et al.

  DOI：——

  日期：——
• Deacylations and Syntheses of Some 9-Acylfluorenes
  作者：Takao Kimura、Masahiro Minabe、Motohiro Tsubota、Kazuo Suzuki

  DOI：10.1246/bcsj.50.258

  日期：1977.1

  Deacylations of substituted 9-acetyl-, 9-propionyl-, 9-benzoyl-fluorene, and 9-fluorenyl 9-methyl-9-fluorenyl ketones were studied; the reactivity of deacylation was enhanced by the substitution of the 9-hydrogen atom on 9-acetylfluorene. The reaction of 9-acetylfluorene with ethyl nitrate afforded 9-aci-nitrofluorene.

  研究了取代的 9-乙酰基-、9-丙酰基-、9-苯甲酰基-芴和 9-芴基 9-甲基-9-芴基酮的脱酰反应；9-乙酰芴上的9-氢原子的取代增强了脱酰反应的反应性。9-乙酰芴与硝酸乙酯反应得到9-乙酰硝基芴。