13,16,19,22-tetraoxatetratriacontane-1,34-diyl bis(4-methylbenzenesulfonate) | 165191-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 13,16,19,22-tetraoxatetratriacontane-1,34-diyl bis(4-methylbenzenesulfonate)
• CAS: 165191-85-5
• 化学式: C₄₄H₇₄O₁₀S₂
• 分子量: 827.198
• InChiKey: KMVAEZSTTTZOEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.28
• 重原子数：
  56.0
• 可旋转键数：
  39.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  123.66
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  N-dodecyl-4,13-diaza-18-crown-6 、 13,16,19,22-tetraoxatetratriacontane-1,34-diyl bis(4-methylbenzenesulfonate) 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 72.0h， 以35%的产率得到O,O'-bis<12-(N'-dodecyldiaza-18-crown-6)dodecyl>tris(ethylene glycol)
  参考文献：
  名称：

  Synthetic Models for Transmembrane Channels: Structural Variations That Alter Cation Flux

  摘要：

  Twelve novel bis- or tris(macrocyclic) compounds have been designed as models for cation-conducting channels that function in phospholipid bilayer vesicle membranes. In general, the channel model systems have the structure ''sidearm-crown-spacer-crown-spacer-crown-sidearm'', although certain features have been altered from compound to compound to assess the structure-activity relationship. Two additional compounds have been prepared exclusively as controls. The ionophores have been incorporated into the membranes either by warming the compound with the preformed vesicle or by incorporation during vesicle formation. The two methods gave identical results within experimental error. Cation flux was assessed by two different analytical methods. In one case, the fluorescent dye pyranine was encapsulated within vesicles containing ionophore. Proton transport was then monitored by changes in dye fluorescence with time following an acid pulse. Ionophoretic activity far most of the compounds was studied using a dynamic NMR method in which the flux rate of Na-23(+) through the bilayer was monitored. All NMR studies were done in conjunction with gramicidin as a control to minimize experimental variations from run to run. Several of the synthetic ionophores showed cation conduction of as much as 40% of the activity of gramicidin. Apparently, small structural changes significantly altered flux rates and two known carriers closely related to the channel formers failed to exhibit measurable transport under comparable conditions.

  DOI：

  10.1021/ja00134a011
• 作为产物：
  描述：

  1,34-bis((tetrahydro-2H-pyran-2-yl)oxy)-13,16,19,22-tetraoxatetratriacontane 在 吡啶 、 对甲苯磺酸 作用下， 以 甲醇 、 氯仿 、 水 为溶剂， 反应 176.0h， 生成 13,16,19,22-tetraoxatetratriacontane-1,34-diyl bis(4-methylbenzenesulfonate)
  参考文献：
  名称：

  Synthetic Models for Transmembrane Channels: Structural Variations That Alter Cation Flux

  摘要：

  Twelve novel bis- or tris(macrocyclic) compounds have been designed as models for cation-conducting channels that function in phospholipid bilayer vesicle membranes. In general, the channel model systems have the structure ''sidearm-crown-spacer-crown-spacer-crown-sidearm'', although certain features have been altered from compound to compound to assess the structure-activity relationship. Two additional compounds have been prepared exclusively as controls. The ionophores have been incorporated into the membranes either by warming the compound with the preformed vesicle or by incorporation during vesicle formation. The two methods gave identical results within experimental error. Cation flux was assessed by two different analytical methods. In one case, the fluorescent dye pyranine was encapsulated within vesicles containing ionophore. Proton transport was then monitored by changes in dye fluorescence with time following an acid pulse. Ionophoretic activity far most of the compounds was studied using a dynamic NMR method in which the flux rate of Na-23(+) through the bilayer was monitored. All NMR studies were done in conjunction with gramicidin as a control to minimize experimental variations from run to run. Several of the synthetic ionophores showed cation conduction of as much as 40% of the activity of gramicidin. Apparently, small structural changes significantly altered flux rates and two known carriers closely related to the channel formers failed to exhibit measurable transport under comparable conditions.

  DOI：

  10.1021/ja00134a011