N-[4-(diethylaminodiazenyl)-2-(2-trimethylsilylethynyl)phenyl]acetamide | 488082-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-(diethylaminodiazenyl)-2-(2-trimethylsilylethynyl)phenyl]acetamide
• CAS: 488082-58-2
• 化学式: C₁₇H₂₆N₄OSi
• 分子量: 330.505
• InChiKey: ZNYTWDZVVVUFGG-UHFFFAOYSA-N

物化性质

• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.21
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  57.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[4-(diethylaminodiazenyl)-2-(2-trimethylsilylethynyl)phenyl]acetamide 在 tris(dibenzylideneacetone)dipalladium (0) copper(l) iodide 、 四丁基氟化铵 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 methyl 2-((2-acetamido-5-(3,3-diethyltriaz-1-en-1-yl)phenyl)ethynyl)-4-(3,3-diethyltriaz-1-en-1-yl)benzoate
  参考文献：
  名称：

  Hydrogen Bond-Stabilized Helix Formation of a m-Phenylene Ethynylene Oligomer

  摘要：

  [GRAPHICS]Incorporation of a single hydrogen bonded beta-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.

  DOI：

  10.1021/ol0270982
• 作为产物：
  描述：

  2-bromo-4-amino-N-acetylaniline 在 tris(dibenzylideneacetone)dipalladium (0) 盐酸 、 copper(l) iodide 、 三乙胺 、 三苯基膦 、 sodium nitrite 作用下， 以 水 、 乙腈 为溶剂， 反应 36.5h， 生成 N-[4-(diethylaminodiazenyl)-2-(2-trimethylsilylethynyl)phenyl]acetamide
  参考文献：
  名称：

  Hydrogen Bond-Stabilized Helix Formation of a m-Phenylene Ethynylene Oligomer

  摘要：

  [GRAPHICS]Incorporation of a single hydrogen bonded beta-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.

  DOI：

  10.1021/ol0270982

文献信息

• Hydrogen Bond-Stabilized Helix Formation of a <i>m</i>-Phenylene Ethynylene Oligomer
  作者：Jennifer M. Cary、Jeffrey S. Moore

  DOI：10.1021/ol0270982

  日期：2002.12.1

  [GRAPHICS]Incorporation of a single hydrogen bonded beta-turn mimic in the backbone of a m-phenylene ethynylene oligomer is shown to affect the thermodynamic properties of the folding reaction. Oligomers 1 and 2 both undergo solvophobic helix formation, but hydrogen bonded oligomer 1 was found to form a more stable helix with a higher tolerance to solvent denaturation than isomeric, non-hydrogen bonded oligomer 2.