thieno<3,4-b>furan | 18546-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: thieno<3,4-b>furan
• 英文别名: Thieno[3,4-b]furan
• CAS: 18546-38-8
• 化学式: C₆H₄OS
• 分子量: 124.163
• InChiKey: FZXOORLHDQZVHN-UHFFFAOYSA-N

物化性质

• 沸点：
  176.9±13.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 4-(furan-2'-ylmethylthio)but-2-ynoate 在 copper chromite hydroxide 、 3,6-二-2-吡啶基-1,2,4,5-四嗪 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 喹啉 、 二氯甲烷 、 氯仿 、 甲苯 为溶剂， 反应 18.17h， 生成 thieno<3,4-b>furan
  参考文献：
  名称：

  串联分子内逆Diels-Alder反应法合成噻吩并[3,4- ]呋喃

  摘要：

  标题化合物的制备方法涉及以下关键步骤：在呋喃和炔属侧基酯之间进行分子内Diels-Alder加成反应，以及随后由3,6-di（吡啶-2'-基）-四嗪。

  DOI：

  10.1016/s0040-4039(00)84712-7

文献信息

• [EN] SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME<br/>[FR] INHIBITEURS DE DCN1 À PETITES MOLÉCULES ET PROCÉDÉS THÉRAPEUTIQUES LES UTILISANT
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2018183411A1

  公开（公告）日：2018-10-04

  Compounds of formula (I) as inhibitors of DCNl and compositions containing the same are disclosed. Methods of using the DCNl inhibitors in the treatment of diseases and conditions wherein inhibition of DCNl provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

  公式（I）的化合物被披露为DCNl的抑制剂，以及含有这些化合物的组合物。还披露了在治疗疾病和病况中使用DCNl抑制剂的方法，其中DCNl的抑制提供益处，如氧化应激相关的疾病和病况、神经退行性疾病和病况、代谢紊乱以及肌肉神经退化。
• Covalent Small Molecule DCN1 Inhibitors and Therapeutic Methods Using the Same
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20180289677A1

  公开（公告）日：2018-10-11

  Small molecule covalent inhibitors of DCN1 and compositions containing the same are disclosed. Methods of using the DCN1 covalent inhibitors in the treatment of diseases and conditions wherein inhibition of DCN1 provides a benefit, like oxidative stress-related diseases and conditions, neurodegenerative diseases and conditions, metabolic disorders, and muscular nerve degeneration, also are disclosed.

  揭示了DCN1的小分子共价抑制剂和含有这些抑制剂的组合物。还揭示了在治疗疾病和状况中使用DCN1共价抑制剂的方法，其中DCN1的抑制提供益处，如氧化应激相关的疾病和状况、神经退行性疾病和状况、代谢紊乱以及肌肉神经退化。
• SYNTHESIS OF THIENO[3,4-b]THIOPHENE, THIENO[3,4-b]FURAN, RELATED COMPOUNDS AND THEIR DERIVATIVES AND USE THEREOF
  申请人：Sotzing Gregory A.

  公开号：US20090326187A1

  公开（公告）日：2009-12-31

  Inexpensive and facile methods of preparing fused heterocycles such as thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds, and their derivatives are disclosed. Also disclosed are regioregular polymers prepared from the fused heterocycles.

  揭示了制备噻吩并[3,4-b]噻吩、噻吩并[3,4-b]呋喃、相关化合物及其衍生物的廉价且简便的方法。还揭示了由这些融合杂环制备的规则寡聚物。
• Versatile synthesis of 3,4-b diheteropentalenes
  作者：Tanmoy Dey、Daminda Navarathne、Michael A. Invernale、Ian D. Berghorn、Gregory A. Sotzing

  DOI：10.1016/j.tetlet.2010.02.036

  日期：2010.4

  We describe a new route for the synthesis of thieno[3,4-b]thiophene, alkyl derivatives thereof, seleno[3,4-b]thiophene, and thieno[3,4-b]furan made from inexpensive starting materials, such as thiophene-2-carboxylic acid and furan-2-carboxylic acid. Such fused heterocycles are of great interest for low band gap organic semiconductors and applications including OLEDs, organic photovoltaic cells, and

  我们描述了一种由廉价的起始原料制备的合成噻吩并[3,4- b ]噻吩，其烷基衍生物，硒代[3,4- b ]噻吩和噻吩并[3,4- b ]呋喃的新途径。作为噻吩-2-羧酸和呋喃-2-羧酸。这样的稠合杂环对于低带隙有机半导体以及包括OLED，有机光伏电池和电致变色的应用非常感兴趣。
• Synthesis of thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds and their derivatives and use thereof
  申请人：The University of Connecticut

  公开号：US08168671B2

  公开（公告）日：2012-05-01

  Inexpensive and facile methods of preparing fused heterocycles such as thieno[3,4-b]thiophene, thieno[3,4-b]furan, related compounds, and their derivatives are disclosed. Also disclosed are regioregular polymers prepared from the fused heterocycles.

  本文揭示了制备融合杂环化合物（如噻吩并[3,4-b]噻吩、噻吩并[3,4-b]呋喃等）及其衍生物的廉价和简便方法。同时还揭示了由这些融合杂环化合物制备的规则构型聚合物。