6-trifluoromethyl-6-methoxycarbonyl-3,4-dimethyl-5,6-dihydro-2H-pyran | 134224-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 6-trifluoromethyl-6-methoxycarbonyl-3,4-dimethyl-5,6-dihydro-2H-pyran
• 英文别名: 6-methoxycarbonyl-6-trifluoromethyl-5,6-dihydro-3,4-dimethyl-2H-pyran；methyl 4,5-dimethyl-2-(trifluoromethyl)-3,6-dihydro-2H-pyran-2-carboxylate；methyl 3,4-dimethyl-6-(trifluoromethyl)-2,5-dihydropyran-6-carboxylate
• CAS: 134224-65-0
• 化学式: C₁₀H₁₃F₃O₃
• 分子量: 238.207
• InChiKey: JXWPSSTYUHCORO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-trifluoromethyl-6-methoxycarbonyl-3,4-dimethyl-5,6-dihydro-2H-pyran 在 氢氧化钾 作用下， 以87%的产率得到3,4-dimethyl-5,6-dihydro-2H-pyran
  参考文献：
  名称：

  Reaction of trifluororacemic acid methyl ester with 1,3-dienes

  摘要：

  The reaction of trifluororacemic acid with 1,3-dienes affords Diels-Alder reaction products in a high yield and with a high degree of specificity. Catalysis by SnCl4 changes the course of the reaction of the ester with isoprene, affording an ene reaction product.

  DOI：

  10.1007/bf00959643
• 作为产物：
  描述：

  三氟丙酮酸甲酯 、 2,3-二甲基-1,3-丁二烯 以 正己烷 为溶剂， 反应 24.0h， 以85%的产率得到6-trifluoromethyl-6-methoxycarbonyl-3,4-dimethyl-5,6-dihydro-2H-pyran
  参考文献：
  名称：

  Reaction of trifluororacemic acid methyl ester with 1,3-dienes

  摘要：

  The reaction of trifluororacemic acid with 1,3-dienes affords Diels-Alder reaction products in a high yield and with a high degree of specificity. Catalysis by SnCl4 changes the course of the reaction of the ester with isoprene, affording an ene reaction product.

  DOI：

  10.1007/bf00959643

文献信息

• Soloshonok, V. A.; Rozhenko, A. B.; Butovich, I. A., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 10, p. 1771 - 1775
  作者：Soloshonok, V. A.、Rozhenko, A. B.、Butovich, I. A.、Kukhar', V. P.

  DOI：——

  日期：——
• SOLOSHONOK, V. A.;ROZHENKO, A. B.;BUTOVICH, I. A.;KUXAR, V. P., ZH. ORGAN. XIMII, 26,(1990) N0, S. 2051-2056
  作者：SOLOSHONOK, V. A.、ROZHENKO, A. B.、BUTOVICH, I. A.、KUXAR, V. P.

  DOI：——

  日期：——
• GOLUBEV, A. S.;GALAXOV, M. V.;KOLOMIETS, A. F.;FOKIN, A. V., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 141-145
  作者：GOLUBEV, A. S.、GALAXOV, M. V.、KOLOMIETS, A. F.、FOKIN, A. V.

  DOI：——

  日期：——
• Reaction of trifluororacemic acid methyl ester with 1,3-dienes
  作者：A. S. Golubev、M. V. Galakhov、A. F. Kolomiets、A. V. Fokin

  DOI：10.1007/bf00959643

  日期：1991.1

  The reaction of trifluororacemic acid with 1,3-dienes affords Diels-Alder reaction products in a high yield and with a high degree of specificity. Catalysis by SnCl4 changes the course of the reaction of the ester with isoprene, affording an ene reaction product.