bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(naphthalene-2,6-diylbis(oxy))diacetate | 1251849-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(naphthalene-2,6-diylbis(oxy))diacetate
• CAS: 1251849-99-6
• 化学式: C₂₂H₁₈N₂O₁₀
• 分子量: 470.392
• InChiKey: ABZDXIPRURGROS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.81
• 重原子数：
  34.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  145.82
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(naphthalene-2,6-diylbis(oxy))diacetate 、 S-三苯甲基-L-半胱氨酸 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以95%的产率得到(2R,2'R)-2,2'-((2,2'-(naphthalene-2,6-diylbis(oxy))bis(acetyl))bis(azanediyl))bis(3-(tritylthio)propanoic acid)
  参考文献：
  名称：

  Amplifying Different [2]Catenanes in an Aqueous Donor−Acceptor Dynamic Combinatorial Library

  摘要：

  Two donor-acceptor [2]catenanes have been synthesized and characterized from a single dynamic combinatorial library in water. One of these catenanes is different from earlier related interlocked molecules in that two donor units stack on each other in an unexpected order. Shifting the equilibrium by choosing the right conditions resulted in a significant increase in the yields of the individual catenanes.

  DOI：

  10.1021/ja906634h
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 2,2'-(naphthalene-2,6-diylbis(oxy))diacetic acid 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以68%的产率得到bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(naphthalene-2,6-diylbis(oxy))diacetate
  参考文献：
  名称：

  Amplifying Different [2]Catenanes in an Aqueous Donor−Acceptor Dynamic Combinatorial Library

  摘要：

  Two donor-acceptor [2]catenanes have been synthesized and characterized from a single dynamic combinatorial library in water. One of these catenanes is different from earlier related interlocked molecules in that two donor units stack on each other in an unexpected order. Shifting the equilibrium by choosing the right conditions resulted in a significant increase in the yields of the individual catenanes.

  DOI：

  10.1021/ja906634h

文献信息

• A Water Soluble Donor-Acceptor [2]Catenane that Can Switch between a Coplanar and a Gemini-Sign Conformation
  作者：Ho Yu Au-Yeung、G. Dan Pantoş、Jeremy K. M. Sanders

  DOI：10.1002/anie.201000807

  日期：——

  moon is in the seventh house: A conformationally switchable donor–acceptor [2]catenane was synthesized from a dynamic combinatorial library in water. The arrangement of the π units in one of the observed conformations features an unprecedented Gemini shape, which is reminiscent of the astrological Gemini sign (see picture). The catenane can be switched between the parallel and nonparallel conformations

  当月亮在第七宫时：从水中的动态组合库合成了构象可转换的供体-受体[2]链烷。π单位在一种观察到的构象中的排列具有前所未有的双子座形状，让人联想到双子星座（见图）。可以在热，化学或疏水性刺激下在平行和非平行构象之间切换连环烷。