4-(2-溴苯氧基)苯甲酸甲酯 | 1044060-55-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-溴苯氧基)苯甲酸甲酯
• 英文名称: methyl 4-(2-bromophenoxy)benzoate
• CAS: 1044060-55-0
• 化学式: C₁₄H₁₁BrO₃
• 分子量: 307.144
• InChiKey: DYTDZRRBZCEGNQ-UHFFFAOYSA-N

物化性质

• 沸点：
  362.7±27.0 °C(Predicted)
• 密度：
  1.434±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-溴苯氧基)苯甲酸甲酯 在 N,N-二甲基乙酰胺 、 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 反应 18.0h， 以95%的产率得到methyl dibenzo[b,d]furan-2-carboxylate
  参考文献：
  名称：

  A Fragment-Based Approach toward Substituted Trioxa[7]helicenes

  摘要：

  A series of novel substituted trioxa[7]helicenes have been successfully prepared by a one-pot palladium catalyzed C-H arylation reaction starting from readily prepared dibenzofuran fragments. The dinitro-substituted helicene was analyzed by X-ray crystallography revealing the occurrence of two distinct enantiomers in the asymmetric unit, which forms interesting supramolecular motifs in the crystal, based on weak H-bonding interactions.

  DOI：

  10.1021/ol3023209
• 作为产物：
  描述：

  对氟苯甲酸 在 N,N-二甲基乙酰胺 、 硫酸 、 potassium carbonate 作用下， 反应 72.0h， 生成 4-(2-溴苯氧基)苯甲酸甲酯
  参考文献：
  名称：

  A Fragment-Based Approach toward Substituted Trioxa[7]helicenes

  摘要：

  A series of novel substituted trioxa[7]helicenes have been successfully prepared by a one-pot palladium catalyzed C-H arylation reaction starting from readily prepared dibenzofuran fragments. The dinitro-substituted helicene was analyzed by X-ray crystallography revealing the occurrence of two distinct enantiomers in the asymmetric unit, which forms interesting supramolecular motifs in the crystal, based on weak H-bonding interactions.

  DOI：

  10.1021/ol3023209

文献信息

• PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS
  申请人：Allen Jennifer R.

  公开号：US20100125062A1

  公开（公告）日：2010-05-20

  Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

  吡啶和嘧啶化合物，以及含有它们的组合物，以及制备这些化合物的方法。本文还提供了治疗通过抑制PDE10可治疗的疾病或疾病的方法，如肥胖症、非胰岛素依赖型糖尿病、精神分裂症、躁郁症、强迫症等。
• Pyridine and pyrimidine derivatives as phosphodiesterase 10 inhibitors
  申请人：Amgen Inc.

  公开号：US08318718B2

  公开（公告）日：2012-11-27

  Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

  吡啶和嘧啶化合物及含有它们的组合物，并且提供了制备这些化合物的方法。此外，本文还提供了一种治疗可通过抑制PDE10治疗的疾病或疾病的方法，例如肥胖症，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。
• FLAP MODULATORS
  申请人：BACANI Genesis M.

  公开号：US20150376212A1

  公开（公告）日：2015-12-31

  The present invention relates to compounds of Formula (I), or a form thereof wherein ring A 1 , R 1 , R 2 , R 3 , R 3 ′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及公式（I）的化合物或其形式，其中环A1、R1、R2、R3、R3'、L、W和V的定义如本文所述，作为FLAP调节剂有用。本发明还涉及包含公式（I）化合物的制药组合物。制备和使用公式（I）化合物的方法也属于本发明的范围。
• US8318718B2
  申请人：——

  公开号：US8318718B2

  公开（公告）日：2012-11-27
• US8759532B2
  申请人：——

  公开号：US8759532B2

  公开（公告）日：2014-06-24