2-Vinyl-pyridin; Hydrochlorid | 2479-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Vinyl-pyridin; Hydrochlorid
• 英文别名: 2-vinyl pyridine hydrochloride；vinylpyridine hydrochloride；2-Vinylpyridinium chloride；2-ethenylpyridin-1-ium;chloride
• CAS: 2479-59-6
• 化学式: C₇H₇N*ClH
• 分子量: 141.6
• InChiKey: YYPLPZPLLWYWKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.15
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Vinyl-pyridin; Hydrochlorid 在 sodium hydroxide 作用下， 以 正丁醇 为溶剂， 反应 5.0h， 生成 Toluene-4-sulfonic acid 2'-methyl-6'-phenyl-[2,3']bipyridinyl-5'-yl ester
  参考文献：
  名称：

  Reaction of vinylpyridines with oxazoles

  摘要：

  DOI：

  10.1007/bf00742844

文献信息

• Method for conversion of beta-hydroxy carbonyl compounds
  申请人：Lilga A. Michael

  公开号：US20070219391A1

  公开（公告）日：2007-09-20

  A process is disclosed for conversion of salts of β-hydroxy carbonyl compounds forming useful conversion products including, e.g., α,β-unsaturated carbonyl compounds and/or salts of α,β-unsaturated carbonyl compounds. Conversion products find use, e.g., as feedstock and/or end-use chemicals.

  揭示了一种将β-羟基羰基化合物的盐转化为有用的转化产物的过程，包括α，β-不饱和羰基化合物和/或α，β-不饱和羰基化合物的盐。这些转化产物可以用作原料或最终用途的化学品。
• Method and apparatus for conversion of beta-hydroxy carbonyl compounds
  申请人：Zacher H. Alan

  公开号：US20070219390A1

  公开（公告）日：2007-09-20

  A process and apparatus are disclosed for conversion of β-hydroxy carbonyl compounds forming useful conversion products including, e.g., acrylic acid [CAS No. 79-10-7], acrylates, and acrylamide [CAS No. 79-06-01]. Conversion products find use, e.g., as feedstock and/or end-use chemicals.

  揭示了一种用于转化β-羟基羰基化合物以形成有用的转化产物的方法和装置，包括丙烯酸[CAS编号79-10-7]、丙烯酸酯和丙烯酰胺[CAS编号79-06-01]等。转化产物可用作原料和/或最终用途化学品。
• [EN] PREPARATION OF ALPHA, BETA-UNSATURATED CARBOXYLIC ACIDS AND ESTERS THEREOF<br/>[FR] PRÉPARATION D'ACIDES CARBOXYLIQUES ALPHA,BÊTA-INSATURÉS ET DE LEURS ESTERS
  申请人：MYRIANT CORP

  公开号：WO2013134385A1

  公开（公告）日：2013-09-12

  An L-type zeolite, a modified L-type zeolite, or any combination thereof may be useful in catalytically preparing α,β-unsaturated carboxylic acids and/or esters thereof through reaction pathways that include dehydroxylation reactions and optionally esterification reactions. In some reaction pathways, dehydroxylation reactions and esterification reactions may be performed sequentially or concurrently.

  一种L型沸石，经过改性的L型沸石，或两者的任意组合可能在催化制备α，β-不饱和羧酸和/或其酯的过程中发挥作用，该过程包括脱羟基反应和可选的酯化反应。在某些反应途径中，脱羟基反应和酯化反应可以顺序或同时进行。
• [EN] NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX DERIVES D'AMINES PYRIDYLETHANOL (PHENYLETHYL) UTILES COMME INHIBITEURS DE LA BIOSYNTHESE DU CHOLESTEROL, LEURS PROCEDES DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：LEK PHARMACEUTICALS

  公开号：WO2004007456A1

  公开（公告）日：2004-01-22

  The novel derivatives of pyridylethanol (phenylethyl) amines of formula I are described wherein n is an integer from 1 to 4, R1 is a hydrogen atom, hydroxyl group or lower C1-6 alkoxy group R2 is a hydrogen atom or a straight or branched lower C1-6 alkyl group X, is hydrogen, fluorine, chlorine, bromine, hydroxyl group, trifluoromethyl group, 3,4-di-CI,2,4-di-CI or lower C1-6 alkoxy group, the enantiomers, diastereoisomers or racemates thereof or the physiologically acceptable acid addition salts thereof which are ligands of sigma receptors for inhibiting cholesterol biosynthesis and are thus appropriate for the treatment of hypercholesterolemia and hyperlipemia in humans. The greatest lowering of cholesterol was observed by 1-(d-pyridyl)-2-(N-(2-(3,4-dicholorophenyl)ethyl-N-propylamino)ethanol in the form of dihydrobromide salt (signature BK-35. 2HBr).

  描述了式I的吡啶乙醇（苯乙基）胺的新颖衍生物，其中n是1到4的整数，R1是氢原子、羟基或较低的C1-6烷氧基团，R2是氢原子或直链或支链的较低的C1-6烷基团，X是氢、氟、氯、溴、羟基、三氟甲基、3,4-二氯、2,4-二氯或较低的C1-6烷氧基团，其对映体、二对映异构体或混合物或其生理上可接受的酸盐是sigma受体的配体，用于抑制胆固醇生物合成，因此适用于治疗人类高胆固醇血症和高脂血症。1-(d-吡啶基)-2-(N-(2-(3,4-二氯苯基)乙基-N-丙基氨基)乙醇在二氢溴化物盐形式中观察到了最大的胆固醇降低作用（签名BK-35.2HBr）。
• [EN] N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR<br/>[FR] N-(2-ARYLETHYL)BENZYLAMINES UTILISEES EN TANT QU'ANTAGONISTES DU RECEPTEUR 5-HT6
  申请人：LILLY CO ELI

  公开号：WO2002078693A2

  公开（公告）日：2002-10-10

  The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor.

  本发明提供了式（I）的化合物，它们是5-HT6受体的拮抗剂。

表征谱图