1-naphthylacetyl-Tyr(Me)-Val-OH | 1158974-87-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-naphthylacetyl-Tyr(Me)-Val-OH
• CAS: 1158974-87-8
• 化学式: C₂₇H₃₀N₂O₅
• 分子量: 462.546
• InChiKey: RWLWDARIZSFBCO-ZCYQVOJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.34
• 重原子数：
  34.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  104.73
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-naphthylacetyl-Tyr(Me)-Val-OH 、 (+)-pinanediol (R)-1-amino-2-phenylethane-1-boronate trifluoroacetate salt 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of boronic acid derivatives of tyropeptin: Proteasome inhibitors

  摘要：

  Boronic acid derivatives of tyropeptin were synthesized with TP-110 as the lead compound. Due to the lability of the aminoboronic acid moiety, careful design of the deprotection and coupling sequence was required. Liquid-liquid partition chromatography was found to be a powerful tool for purification of compounds of this class. The obtained derivatives showed potent inhibitory activities against the human 20S proteasome in vitro. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.117