4-chloro-N-[5-oxo-4-(pyridine-3-carbonyl)-1,3,4-thiadiazol-2-yl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-[5-oxo-4-(pyridine-3-carbonyl)-1,3,4-thiadiazol-2-yl]benzamide
• 化学式: C₁₅H₉ClN₄O₃S
• 分子量: 360.78
• InChiKey: WDIMPSVYDLVGSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  异硫氰酸 p-氯苯甲酰脂 在 sodium acetate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 4-chloro-N-[5-oxo-4-(pyridine-3-carbonyl)-1,3,4-thiadiazol-2-yl]benzamide
  参考文献：
  名称：

  Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity

  摘要：

  A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00073-1

文献信息

• Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity
  作者：Silvia Schenone、Olga Bruno、Angelo Ranise、Francesco Bondavalli、Walter Filippelli、Giuseppe Falcone、Brunella Piucci、Salvatore Sorrentino

  DOI：10.1016/s0014-827x(98)00073-1

  日期：1998.8

  A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties. (C) 1998 Elsevier Science S.A. All rights reserved.