2-pyrrolidinone-4-acetic acid | 32741-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-pyrrolidinone-4-acetic acid
• 英文别名: 2-(5-Oxopyrrolidin-3-yl)acetic acid
• CAS: 32741-98-3
• 化学式: C₆H₉NO₃
• mdl: MFCD19220598
• 分子量: 143.142
• InChiKey: YKTYYHBGRGVBPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-pyrrolidinone-4-acetic acid 在 dirhodium tetraacetate 、 p-dodecylsulfonyl azide 、 TEA 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 生成 3-Methoxy-7-oxo-1-aza-bicyclo[3.2.1]oct-3-ene-2-carboxylic acid 4-nitro-benzyl ester
  参考文献：
  名称：

  Design and synthesis of bridged γ-lactams as analogues of β-lactam antibiotics

  摘要：

  Anti-Bredt bridged bicyclo[3.2.1] gamma-lactams were designed as inhibitors of penicillin binding proteins (PBPs). The compounds were prepared by a carbenoid insertion into a lactam N-H bond. Their weak antibacterial activity could either be explained by a poor chemical stability or by unfavorable steric interactions of the methylene bridge of the gamma-lactam with the targeted enzymes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.004
• 作为产物：
  描述：

  E-戊二酸二乙酯 在 palladium on activated charcoal 氢氧化钾 、 氢气 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 2-pyrrolidinone-4-acetic acid
  参考文献：
  名称：

  Design and synthesis of bridged γ-lactams as analogues of β-lactam antibiotics

  摘要：

  Anti-Bredt bridged bicyclo[3.2.1] gamma-lactams were designed as inhibitors of penicillin binding proteins (PBPs). The compounds were prepared by a carbenoid insertion into a lactam N-H bond. Their weak antibacterial activity could either be explained by a poor chemical stability or by unfavorable steric interactions of the methylene bridge of the gamma-lactam with the targeted enzymes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.004

文献信息

• Thrombin inhibitors
  申请人：Eli Lilly and Company

  公开号：US06391901B1

  公开（公告）日：2002-05-21

  This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of defined compounds of formula I as thrombin inhibitors.

  这项申请涉及到式I的新化合物（及其药学上可接受的盐），如本文所定义，用于它们的制备的过程和中间体，包含式I的新化合物的药物配方，以及将式I的特定化合物用作凝血酶抑制剂。
• Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases
  申请人：——

  公开号：US20010034343A1

  公开（公告）日：2001-10-25

  The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula 1 and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

  本发明涉及一种新颖的4-(1H-苯并咪唑-2-基)[1,4]二氮杂环庚烷衍生物及其立体异构体，以及其药学上可接受的盐，其作为组胺受体拮抗剂和速激肽受体拮抗剂具有用途。这些拮抗剂在过敏性鼻炎的治疗中有用，包括季节性鼻炎和鼻窦炎；炎症性肠病，包括克罗恩病和溃疡性结肠炎；哮喘；支气管炎；以及呕吐。
• Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses
  申请人：Celanire Sylvain

  公开号：US20090023708A1

  公开（公告）日：2009-01-22

  The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as pharmaceuticals.

  本发明涉及公式（I）的化合物，包括内酰胺或内酰胺衍生物基团，制备它们的过程，包括所述化合物的制药组合物以及它们作为药物的用途。
• 1-Benzoyl-2-pyrrolidinonderivat, Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0005143A1

  公开（公告）日：1979-11-14

  1-(p-Methoxybenzoyl)-2-pyrrolidinon, verwendbar bei der Bekämpfung bzw. Verhütung der cerebralen Insuffizienz bzw. bei der Verbesserung der intellektuellen Leistungsfähigkeit.

  1-（对甲氧基苯甲酰基）-2-吡咯烷酮，可用于治疗或预防脑功能不全或提高智力。
• Pyrrolidone, piperidone and azetidinone terminated and functionalizes dendritic polymers
  申请人：Tomalia A. Donald

  公开号：US20050171298A1

  公开（公告）日：2005-08-04

  Heterocycle terminated dendritic polymers. More specifically, the production of 2-pyrrolidone, 2-piperidone, 2-aza-cycloheptanone or 2-azetidinone-terminated dendritic polymers obtained by reacting precursor primary amine,(e.g., —NH 2 )-terminated dendritic polymers with certain functionalized methacrylate reagents to produce new and novel dendritic polymers terminated with ester substituted 2-pyrrolidone, 2-piperidone, 2-aza-cycloheptanone or 2-azetidinone groups.

  杂环封端树枝状聚合物。更具体地说，生产 2-吡咯烷酮、2-哌啶酮、2-氮杂环庚酮或 2-氮杂环丁酮末端树枝状聚合物，是通过前体伯胺（如 -NH 2 )封端的树枝状聚合物与某些官能化甲基丙烯酸酯试剂反应，生产出以酯取代的 2-吡咯烷酮、2-哌啶酮、2-氮杂环庚酮或 2-氮杂环丁酮基团封端的新型树枝状聚合物。