(9CI)-5-(4-溴苯基)-2-甲基嘧啶 | 131548-21-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (9CI)-5-(4-溴苯基)-2-甲基嘧啶
• 英文名称: 5-(p-bromophenyl)-2-methylpyrimidine
• 英文别名: 5-(4-bromophenyl)-2-methylpyrimidine
• CAS: 131548-21-5
• 化学式: C₁₁H₉BrN₂
• 分子量: 249.11
• InChiKey: ILUGQMCJLKLOFU-UHFFFAOYSA-N

物化性质

• 沸点：
  342.7±25.0 °C(Predicted)
• 密度：
  1.434±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (9CI)-5-(4-溴苯基)-2-甲基嘧啶 在 sodium methylate 、 三氯氧磷 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 8.0h， 生成 2-(p-hexyloxyphenyl)-5'-(p-bromophenyl)-2',5-bipyrimidine
  参考文献：
  名称：

  2,5'-取代的2'，5-联嘧啶的合成

  摘要：

  DOI：

  10.1007/bf00756421
• 作为产物：
  描述：

  盐酸乙脒 、 N-(2-(4-bromophenyl)-3-(dimethylamino)allylidene)-N-methylmethanaminium perchlorate 在 吡啶 作用下， 反应 12.0h， 以71%的产率得到(9CI)-5-(4-溴苯基)-2-甲基嘧啶
  参考文献：
  名称：

  Synthesis of Oligo(diazaphenyls). Tailor-Made Fluorescent Heteroaromatics and Pathways to Nanostructures

  摘要：

  苯并、联苯、四苯、五苯、六苯、七苯、八苯、九苯、十苯和十二苯的寡氮杂衍生物以及聚(嘧啶亚苯基亚苯)可以从易得的乙烯胺盐和胺或N,N,N'-三(三甲基硅基)胺合成。通过改变N原子的数量和位置，这些体系的荧光可以在广泛的光谱范围内调节。寡(二氮苯)在热和光化学上是稳定的，比寡苯更容易还原，在强酸中可以以任意速率溶解，并且在溶液中以及固态中显示强烈的蓝色荧光。

  DOI：

  10.1055/s-1997-1405

文献信息

• [EN] N-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS D'ACIDE HYDROXAMIQUE À LIAISON N, UTILES COMME AGENTS ANTIBACTÉRIENS
  申请人：PFIZER

  公开号：WO2011073845A1

  公开（公告）日：2011-06-23

  The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections. Formula (I).

  本发明涉及一类新的羟肟酸衍生物，它们作为LpxC抑制剂的用途，更具体地用于治疗细菌感染。公式（I）。
• N-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents
  申请人：Brown Matthew Frank

  公开号：US20120258948A1

  公开（公告）日：2012-10-11

  The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R 1 , R 2 , R 3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.

  本发明涉及一种新的羟肟酸衍生物类别，其化学式为I，其中变量G，T，D，L，R1，R2，R3如本文所述，其用作LpxC抑制剂，更具体地用于治疗有需要的患者的细菌感染。
• N-Link Hydroxamic Acid Derivatives Useful As Antibacterial Agents
  申请人：Pfizer Inc.

  公开号：US20140128363A1

  公开（公告）日：2014-05-08

  The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.

  本发明涉及一种新的羟肟酸衍生物类，其用作LpxC抑制剂，更具体地用于治疗细菌感染。
• N-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
  申请人：Pfizer Inc.

  公开号：EP2512474A1

  公开（公告）日：2012-10-24
• LAMINATED STRUCTURE, METHOD FOR PRODUCING SAME, AND ELECTRONIC ELEMENT COMPRISING SAME
  申请人：Tanaka Kenta

  公开号：US20110177312A1

  公开（公告）日：2011-07-21

  A laminated structure comprising an electrode, a polymer binding layer arranged on the electrode, and an electrically conductive organic material layer arranged on the polymer binding layer, wherein the polymer binding layer comprises an aromatic polymeric compound which has a structure represented by formula (I) [wherein Ar represents a conjugated divalent group which may have a substituent, provided that when there are multiple Ar's, the Ar's may be the same as or different from each other; and n represents an integer of 1 or greater] and has a number average molecular weight of 1×10 3 to 1×10 8 inclusive in terms of polystyrene content, the polymer binding layer is bonded to the electrode via a chemical bond between the aromatic polymeric compound and the surface of the electrode, and an electrically conductive organic material that composes a layer included in the electrically conductive organic material layer and arranged adjacent to the polymer binding layer has a number average molecular weight of 3×10 2 to 1×10 8 inclusive in terms of polystyrene content.