5-fluoro-2,6-dimethylpyrimidin-4-ol | 654-41-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-fluoro-2,6-dimethylpyrimidin-4-ol
• 英文别名: 5-Fluoro-2,6-dimethylpyrimidin-4(1h)-one；5-fluoro-2,4-dimethyl-1H-pyrimidin-6-one
• CAS: 654-41-1
• 化学式: C₆H₇FN₂O
• 分子量: 142.133
• InChiKey: LINWSDIYFZGXLA-UHFFFAOYSA-N

物化性质

• 熔点：
  177-178℃ (ethanol )

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  5-fluoro-2,6-dimethylpyrimidin-4-ol 在 三氯氧磷 作用下， 反应 1.0h， 以88.51%的产率得到4-chloro-5-fluoro-2,6-dimethylpyrimidine
  参考文献：
  名称：

  [EN] BAX INHIBITORS AND USES THEREOF
  [FR] INHIBITEURS DE BAX ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2021002986A3
• 作为产物：
  描述：

  2-氟乙酰乙酸乙酯 、 盐酸乙脒 在 sodium methylate 作用下， 生成 5-fluoro-2,6-dimethylpyrimidin-4-ol
  参考文献：
  名称：

  Source regions and timescales for the delivery of water to the Earth

  摘要：

  Abstract—In the primordial solar system, the most plausible sources of the water accreted by the Earth were in the outer asteroid belt, in the giant planet regions, and in the Kuiper Belt. We investigate the implications on the origin of Earth's water of dynamical models of primordial evolution of solar system bodies and check them with respect to chemical constraints. We find that it is plausible that the Earth accreted water all along its formation, from the early phases when the solar nebula was still present to the late stages of gas‐free sweepup of scattered planetesimals. Asteroids and the comets from the Jupiter‐Saturn region were the first water deliverers, when the Earth was less than half its present mass. The bulk of the water presently on Earth was carried by a few planetary embryos, originally formed in the outer asteroid belt and accreted by the Earth at the final stage of its formation. Finally, a late veneer, accounting for at most 10% of the present water mass, occurred due to comets from the Uranus‐Neptune region and from the Kuiper Belt. The net result of accretion from these several reservoirs is that the water on Earth had essentially the D/H ratio typical of the water condensed in the outer asteroid belt. This is in agreement with the observation that the D/H ratio in the oceans is very close to the mean value of the D/H ratio of the water inclusions in carbonaceous chondrites.

  DOI：

  10.1111/j.1945-5100.2000.tb01518.x

文献信息

• BAX INHIBITORS AND USES THEREOF
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20220389028A1

  公开（公告）日：2022-12-08

  A compound having formula (I) or (II) for use inhibiting Bax mediated cell death and/or apoptosis.
• [EN] KRAS G12C INHIBITORS<br/>[FR] INHIBITEURS DE KRAS G12C
  申请人：[en]FRONTIER MEDICINES CORPORATION

  公开号：WO2023081840A1

  公开（公告）日：2023-05-11

  The present disclosure provides compounds and methods useful in the treatment and suppression of cancer, for example, useful for treating or suppressing cancers characterized by KRAS G12C. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
• [EN] BAX INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE BAX ET LEURS UTILISATIONS
  申请人：UNIV CASE WESTERN RESERVE

  公开号：WO2021002986A3

  公开（公告）日：2021-05-27
• Source regions and timescales for the delivery of water to the Earth
  作者：A. Morbidelli、J. Chambers、J. I. Lunine、J. M. Petit、F. Robert、G. B. Valsecchi、K. E. Cyr

  DOI：10.1111/j.1945-5100.2000.tb01518.x

  日期：2000.11

  Abstract—In the primordial solar system, the most plausible sources of the water accreted by the Earth were in the outer asteroid belt, in the giant planet regions, and in the Kuiper Belt. We investigate the implications on the origin of Earth's water of dynamical models of primordial evolution of solar system bodies and check them with respect to chemical constraints. We find that it is plausible that the Earth accreted water all along its formation, from the early phases when the solar nebula was still present to the late stages of gas‐free sweepup of scattered planetesimals. Asteroids and the comets from the Jupiter‐Saturn region were the first water deliverers, when the Earth was less than half its present mass. The bulk of the water presently on Earth was carried by a few planetary embryos, originally formed in the outer asteroid belt and accreted by the Earth at the final stage of its formation. Finally, a late veneer, accounting for at most 10% of the present water mass, occurred due to comets from the Uranus‐Neptune region and from the Kuiper Belt. The net result of accretion from these several reservoirs is that the water on Earth had essentially the D/H ratio typical of the water condensed in the outer asteroid belt. This is in agreement with the observation that the D/H ratio in the oceans is very close to the mean value of the D/H ratio of the water inclusions in carbonaceous chondrites.