5-(3-羟基丙氧基)-2-硝基苯甲醛 | 207298-34-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-(3-羟基丙氧基)-2-硝基苯甲醛
• 英文名称: 2-Nitro-5-(3-hydroxypropoxy)benzaldehyde
• 英文别名: 5-(3-Hydroxypropoxy)-2-nitrobenzaldehyde
• CAS: 207298-34-8
• 化学式: C₁₀H₁₁NO₅
• 分子量: 225.201
• InChiKey: NJWLMMIPAPQNIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  咪唑 、 5-(3-羟基丙氧基)-2-硝基苯甲醛 在 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 以1.44 g (96%)的产率得到2-nitro-5-(3-O-t-butyldimethylsilylpropoxy) benzaldehyde
  参考文献：
  名称：

  DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY

  摘要：

  提供了快速和高精度的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。

  公开号：

  US20020042112A1
• 作为产物：
  描述：

  5-羟基-2-硝基苯甲醛 、 3-溴-1-丙醇 在 potassium carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 5-(3-羟基丙氧基)-2-硝基苯甲醛
  参考文献：
  名称：

  DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY

  摘要：

  提供了快速和高精度的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。

  公开号：

  US20020042112A1

文献信息

• DNA Diagnostics Based on Mass Spectrometry
  申请人：Koster Hubert

  公开号：US20090023150A1

  公开（公告）日：2009-01-22

  Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  提供了快速和高度准确的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或状况的易感性，病原体感染，或用于确定身份或遗传。
• High density immobilization of nucleic acids
  申请人：Sequenom, Inc.

  公开号：US06818394B1

  公开（公告）日：2004-11-16

  Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array, The prepared sample arrays may be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.

  本发明公开了用于将高密度核酸固定在不溶性表面上的工艺和试剂盒，特别适用于质谱检测核酸。本发明还提供了包含固定核酸的阵列，并将固定核酸用于各种固相核酸化学应用，包括核酸合成（化学和酶促）、杂交和/或延伸以及测序。此外，还提供了串行和并行分配工具，可提供定义的液体体积，以在基板表面生成多元素样品阵列。所提供的工具可以包括一个小泡元件或针，其中每个针可以包括一个适用于容纳纳升级液体的窄内腔。还提供了用于分配工具的方法，可用于在基板表面上生成多元素样品阵列。该工具可以通过从针喷射液体、接触基板表面或形成接触基板表面的液滴，向基板表面分配液体斑点。该工具可以通过在移动针到基板表面上不同位置的同时，在一系列步骤中分配样品材料来形成样品阵列。制备好的样品阵列可以传递给一个板组件，该板组件将样品阵列放置以通过质谱分析进行分析。
• Mass spectrometric detection of polypeptides
  申请人：Sequenom, Inc.

  公开号：US06322970B1

  公开（公告）日：2001-11-27

  A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity. Kits for performing the disclosed processes also are provided.

  提供了一种使用质谱法确定目标多肽的身份的过程。根据要识别的目标多肽，可以使用公开披露的过程，例如，用于诊断遗传疾病或染色体异常、疾病或状况的易感性，或感染病原体；或用于确定身份或遗传。还提供了执行公开披露的过程的试剂盒。
• DNA diagnostics based on mass spectrometry
  申请人：Sequenom, Inc.

  公开号：US07198893B1

  公开（公告）日：2007-04-03

  Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

  提供了快速且高精度的基于质谱的过程，用于检测生物样本中的特定核酸序列。根据要检测的序列，这些过程可以用于诊断遗传疾病或染色体异常；疾病或情况的易感性，病原体感染，或用于确定身份或遗传。
• high density immobilization of nucleic acids
  申请人：SEQUENOM, INC.

  公开号：EP1457496A1

  公开（公告）日：2004-09-15

  The invention provides a dispensing apparatus for dispensing nanovolumes of fluid in chemical or biological procedures onto the surface of a substrate, comprising: a housing having a plurality of sides and a bottom portion having formed therein a plurality of apertures, said sides and bottom portion of said housing defining an interior volume, one or more fluid transmitting vesicles, mounted within said apertures, having a nanovolume sized fluid holding chamber for holding nanovolumes of fluid, said fluid holding chamber being disposed in fluid communication with said interior volume of said housing, and dispensing means in communication with said interior volume of said housing for selectively dispensing nanovolumes of fluid from said nanovolume sized fluid transmitting vesicles when the fluid is loaded with said fluid holding chambers of said vesicles, whereby said dispensing means dispenses nanovolumes of the fluid onto the surface of the substrate when the apparatus is disposed over and in registration with the substrate.

  本发明提供了一种分配装置，用于在化学或生物程序中将纳米体积的流体分配到基底表面，该装置包括 具有多个侧面和底部的壳体，壳体的侧面和底部形成多个孔，壳体的侧面和底部限定了内部容积、 一个或多个流体传输囊泡，安装在所述孔内，具有纳米体积大小的流体容纳腔，用于容纳纳米体积的流体，所述流体容纳腔与所述外壳的内部容积流体相通，以及 与所述外壳的所述内部容积相通的分配装置，用于在流体装入所述囊泡的所述流体容纳室时，从所述纳米容积大小的流体传输囊泡中选择性地分配纳米容积的流体，从而当设备放置在基底上方并与基底相匹配时，所述分配装置将纳米容积的流体分配到基底的表面上。