乙内酰脲-8-乙酸氯 | 51876-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 中文名称: 乙内酰脲-8-乙酸氯
• 英文名称: Hydantoin-5-acetylchlorid
• 英文别名: (2,5-dioxo-imidazolidin-4-yl)-acetyl chloride；5-hydantoin acetyl chloride；(2,5-Dioxoimidazolidin-4-yl)acetyl chloride；2-(2,5-dioxoimidazolidin-4-yl)acetyl chloride
• CAS: 51876-11-0
• 化学式: C₅H₅ClN₂O₃
• mdl: MFCD02094026
• 分子量: 176.559
• InChiKey: IKJILNBIBFSCFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-氨基噻唑 、 乙内酰脲-8-乙酸氯 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.17h， 生成 2-(2,4-dioxo-imidazolidin-5-yl)-N-thiazol-2-yl-acetamide
  参考文献：
  名称：

  Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives

  摘要：

  The synthesis and evaluation of anticancer activity of 2,4-thia(imida)zolidinedione-3- and 5-acetic acids amides were described. The structures of compounds were determined by IR, H-1 NMR, and MS analysis. In vitro anticancer activity of these compounds has been tested in National Cancer Institute (NCI) and the relationships between structure and anticancer activity are discussed. Among 2,4-azolidinedione-acetic acids derivatives 2-[5-(4-chlorobenzylidene)-2,4-dioxo-imidazolidin-3-yl]-N-(2-trifluoromethyl-phenyl)-acetamide (Ic) was superior to other related compounds in terms of high selectivity for the leukemia CCRF-CEM (log GI(50) = -6.06), HL-60(TB) (log GI(50) = -6.53), MOLT-4 (log GI(50) = -6.52) and SR (log GI(50) -6.51) cell lines. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.02.023
• 作为产物：
  描述：

  5-海因乙酸 在 氯化亚砜 作用下， 反应 120.0h， 以22%的产率得到乙内酰脲-8-乙酸氯
  参考文献：
  名称：

  WO2006/135406

  摘要：

  公开号：

文献信息

• Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof
  申请人：Fensholdt Jef

  公开号：US20070244117A1

  公开（公告）日：2007-10-18

  The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R 1 , A, R 9 , X, B, R 8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.

  本发明涉及一般式I的化合物，其中D、E、F、G、W、Y、R1、A、R9、X、B、R8如本文所定义，并且其药学上可接受的盐、水合物或溶剂化物，用于治疗与异常血管生成相关的疾病，如癌症，可单独使用或与一个或多个其他药理活性化合物联合使用。
• NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES
  申请人：Fensholdt Jef

  公开号：US20100317582A1

  公开（公告）日：2010-12-16

  The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

  本发明涉及新的环烃化合物及其衍生物，其制备方法，以及将这些化合物用作药物、治疗用化合物、包含这些化合物的药物组合物、使用这些化合物治疗疾病的方法，以及将这些化合物用于药物制造的用途。
• HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF
  申请人：LEO PHARMA A/S

  公开号：EP1697312B1

  公开（公告）日：2011-07-20
• Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents
  申请人：Denkewicz P. Raymond

  公开号：US20070014754A1

  公开（公告）日：2007-01-18

  The present invention describes compositions and methods for sorbing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological and chemical warfare agents.
• FUNCTIONALIZED DENDRITIC POLYMERS FOR THE CAPTURE AND NEUTRALIZATION OF BIOLOGICAL AND CHEMICAL AGENTS
  申请人：Mahmud Khaled

  公开号：US20070071713A1

  公开（公告）日：2007-03-29

  The present invention describes compositions and methods for trapping/capturing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological and chemical warfare agents.