2-amino-N-[6-(6-pyrimidin-2-yl-1,2,4,5-tetrazin-3-yl)pyridin-3-yl]acetamide | 1360535-80-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-N-[6-(6-pyrimidin-2-yl-1,2,4,5-tetrazin-3-yl)pyridin-3-yl]acetamide
• CAS: 1360535-80-3
• 化学式: C₁₃H₁₁N₉O
• 分子量: 309.29
• InChiKey: OXMQIGXGFLGYFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  145
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  tert-Butyl (2-oxo-2-((6-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)pyridin-3-yl)amino)ethyl)carbamate 生成 2-amino-N-[6-(6-pyrimidin-2-yl-1,2,4,5-tetrazin-3-yl)pyridin-3-yl]acetamide
  参考文献：
  名称：

  遗传编码的降冰片烯通过快速生物正交反应指导位点特异性细胞蛋白标记

  摘要：

  通过遗传密码扩展对生物正交基团进行位点特异性结合，为使用任何探针对蛋白质进行位点特异性标记提供了强大的通用策略。然而，可以遗传编码的生物正交官能团的缓慢反应性限制了该策略的实用性。我们在大肠杆菌和哺乳动物细胞中使用吡咯赖氨酰 tRNA 合成酶/tRNA CUA对证明了降冰片烯氨基酸的遗传编码。我们开发了一系列基于四嗪的探针，它们在与降冰片烯的快速反应中表现出“开启”荧光。我们证明编码的降冰片烯的标记对于整个可溶性大肠杆菌是特异性的蛋白质组学，并且比已建立的可编码生物正交反应快数千倍。我们明确地展示了这种方法相对于最先进的生物正交反应在体外和哺乳动物细胞上进行蛋白质标记的优势，并证明了哺乳动物细胞表面蛋白质的快速生物正交位点特异性标记。

  DOI：

  10.1038/nchem.1250

文献信息

• [EN] TETRAZINE AS A TRIGGER TO RELEASE CAGED CARGO<br/>[FR] TÉTRAZINE COMME DÉCLENCHEUR AFIN DE LIBÉRER UNE CHARGE ENFERMÉE DANS UNE CAGE
  申请人：UNIV COURT UNIV OF EDINBURGH

  公开号：WO2017046602A1

  公开（公告）日：2017-03-23

  There is presented a kit comprising a masked active agent and a tetrazine trigger, the masked active agent comprising an active agent connected to a masking moiety comprising a monovinyl ether or an active agent enclosed within a cage moiety comprising a monovinyl ether or an allyl group, wherein the tetrazine trigger is configured to release the active agent from the masking moiety or the cage moiety. Methods of preparing the masked active agents, and uses of the kit are also presented.

  提供了一个套装，包括一个掩蔽活性剂和一个四氮唑触发剂，其中掩蔽活性剂包括连接到包含单乙烯醚的掩蔽基团或包含单乙烯醚或烯丙基团的笼基团的活性剂，四氮唑触发剂被配置为从掩蔽基团或笼基团中释放活性剂。还提供了制备掩蔽活性剂的方法以及套装的用途。
• Rubber composition for tires, and pneumatic tires
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：US11370899B2

  公开（公告）日：2022-06-28

  The present invention provides a rubber composition for tires which provides a balanced improvement in ice performance, fuel economy, and abrasion resistance, and a pneumatic tire containing the rubber composition. The present invention relates to a rubber composition for tires containing a rubber component including at least 80% by mass in total of at least one of an isoprene-based rubber, a polybutadiene rubber, or a styrene-butadiene rubber, the rubber composition containing, per 100 parts by mass of the rubber component, 10 to 120 parts by mass of silica, 0.2 to 10 parts by mass of a tetrazine compound of formula (1), and 1 to 50 parts by mass of a low-molecular-weight diene polymer having a weight average molecular weight of 200,000 or less.

  本发明提供了一种用于轮胎的橡胶组合物，可均衡地改善轮胎的抗冰性能、燃油经济性和耐磨性，还提供了一种含有该橡胶组合物的充气轮胎。本发明涉及一种用于轮胎的橡胶组合物，该橡胶组合物含有一种橡胶成分，该橡胶成分包括异戊二烯基橡胶、聚丁二烯橡胶或丁苯橡胶中的至少一种，按总质量计至少占 80%，该橡胶组合物每 100 份（质量）橡胶成分中含有 10 至 120 份（质量）白炭黑、0.2 至 10 份（质量份）式 (1) 的四嗪化合物，以及 1 至 50 份（质量份）重量平均分子量为 200,000 或以下的低分子量二烯聚合物。
• Pneumatic tire
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：US11396590B2

  公开（公告）日：2022-07-26

  The present invention provides a pneumatic tire achieving a balanced improvement in fuel economy, abrasion resistance, and wet grip performance. The present invention relates to a pneumatic tire, including a tread containing a tread rubber composition, the tread rubber composition containing a rubber component including 30% by mass or more of a styrene-butadiene rubber, the tread rubber composition containing, per 100 parts by mass of the rubber component: 80 to 150 parts by mass of silica; 0.1 to 3.0 parts by mass of a tetrazine compound of formula (1); and 50 parts by mass or less of a hydrocarbon resin having a SP value of 7.5 to 10.5, the styrene-butadiene rubber having a styrene content of 23% by mass or higher.

  本发明提供了一种在燃油经济性、耐磨性和湿地抓地力性能方面实现平衡改善的充气轮胎。本发明涉及一种充气轮胎，包括含有胎面橡胶组合物的胎面，胎面橡胶组合物含有一种橡胶成分，其中包括 30% 或更多质量的丁苯橡胶，胎面橡胶组合物每 100 份质量的橡胶成分含有：80 至 150 份质量的白炭黑；0.1 至 3.0 质量份的式（1）四氮化合物；以及 50 质量份或更少 SP 值为 7.5 至 10.5 的碳氢化合物树脂，丁苯橡胶的苯乙烯含量为 23% 或更高。
• RUBBER COMPOSITION FOR TIRES AND PNEUMATIC TIRE
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：EP3501846B1

  公开（公告）日：2020-04-22
• RUBBER COMPOSITION FOR TIRES, AND PNEUMATIC TIRES
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：US20200048437A1

  公开（公告）日：2020-02-13

  The present invention provides a rubber composition for tires which provides a balanced improvement in ice performance, fuel economy, and abrasion resistance, and a pneumatic tire containing the rubber composition. The present invention relates to a rubber composition for tires containing a rubber component including at least 80% by mass in total of at least one of an isoprene-based rubber, a polybutadiene rubber, or a styrene-butadiene rubber, the rubber composition containing, per 100 parts by mass of the rubber component, 10 to 120 parts by mass of silica, 0.2 to 10 parts by mass of a tetrazine compound of formula (1), and 1 to 50 parts by mass of a low-molecular-weight diene polymer having a weight average molecular weight of 200,000 or less.