L-prolyl lipoic acid | 914454-35-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-prolyl lipoic acid
• 英文别名: (S)-1-(5-(1,2-dithiolan-3-yl)pentanoyl)pyrrolidine-2-carboxylic acid；(2S)-1-[5-(dithiolan-3-yl)pentanoyl]pyrrolidine-2-carboxylic acid
• CAS: 914454-35-6
• 化学式: C₁₃H₂₁NO₃S₂
• 分子量: 303.447
• InChiKey: WVEUVQUXXSXSES-DTIOYNMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  L-prolyl lipoic acid 在 sodium tetrahydroborate 、 乙醇 、 氯化铵 作用下， 反应 2.0h， 生成 (S)-1-(6,8-dimercaptooctanoyl)pyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS)-RELATED DISORDERS
  [FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE TROUBLES LIÉS AU SYSTÈME RÉNINE-ANGIOTENSINE-ALDOSTÉRONE (SRAA)

  摘要：

  公开号：

  WO2010045575A3
• 作为产物：
  描述：

  L-prolyl methyl ester lipoic acid 在 potassium hydroxide 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以75%的产率得到L-prolyl lipoic acid
  参考文献：
  名称：

  [EN] DIHYDROLIPOIC ACID DERIVATIVES COMPRISING NITRIC OXIDE AND THERAPEUTIC USES THEREOF
  [FR] DÉRIVÉS D'ACIDE DIHYDROLIPOÏQUE COMPRENANT DE L'OXYDE NITRIQUE ET LEURS UTILISATIONS THÉRAPEUTIQUES

  摘要：

  公开号：

  WO2010096677A3

文献信息

• [EN] DIHYDROLIPOIC ACID DERIVATIVES COMPRISING NITRIC OXIDE AND THERAPEUTIC USES THEREOF<br/>[FR] DÉRIVÉS D'ACIDE DIHYDROLIPOÏQUE COMPRENANT DE L'OXYDE NITRIQUE ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：INVASC THERAPEUTICS INC

  公开号：WO2010096677A3

  公开（公告）日：2010-12-09
• Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders
  申请人：Rajagopal Desikan

  公开号：US20110257130A1

  公开（公告）日：2011-10-20

  Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related disorder. These compounds include lipoic acid derivatives such as prolyl lipoic acid and pipecolinyl lipoic acid, and other compounds, and these compounds are useful in treating hypertension, stroke, or other renin-angiotensin aldosterone system-related disorders in human or animal patients. Pharmaceutical compositions prepared using these compounds and methods of treatment using these compounds are also provided.
• Dihydrolipoic Acid Derivatives Comprising Nitric Oxide and Therapeutic Uses Thereof
  申请人：Parthasarathy Sampath

  公开号：US20120041025A1

  公开（公告）日：2012-02-16

  Compounds are provided that comprise dinitroso-derivatives of dihydrolipoic acid. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating various diseases and disorders, including angina, hypertension, diabetes, dyslipidemia, renal insufficiency, myocardial infarction, stroke, atherosclerosis, and the target organ damage that accompanies these various diseases and disorders, are further provided. The compounds are useful in improving vasodilation, reducing low-density lipoprotein oxidation, and reducing inflammation in a subject.
• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF RENIN-ANGIOTENSIN ALDOSTERONE SYSTEM (RAAS)-RELATED DISORDERS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE TROUBLES LIÉS AU SYSTÈME RÉNINE-ANGIOTENSINE-ALDOSTÉRONE (SRAA)
  申请人：INVASC THERAPEUTICS INC

  公开号：WO2010045575A3

  公开（公告）日：2010-07-08