2-(4-Methoxyphenyl)-3-pyridin-3-ylprop-2-enenitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-Methoxyphenyl)-3-pyridin-3-ylprop-2-enenitrile
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: RQWSCDRFGHLEGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  45.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Methoxyphenyl)-3-pyridin-3-ylprop-2-enenitrile 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 2-(4-Methoxyphenyl)-3-pyridin-3-ylpropanenitrile
  参考文献：
  名称：

  Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

  摘要：

  We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.036
• 作为产物：
  描述：

  3-吡啶甲醛 、 对甲氧基苯乙腈 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 2-(4-Methoxyphenyl)-3-pyridin-3-ylprop-2-enenitrile
  参考文献：
  名称：

  Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

  摘要：

  We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.036

文献信息

• Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1
  作者：Michele C. Jetter、Mark A. Youngman、James J. McNally、Mark E. McDonnell、Sui-Po Zhang、Adrienne E. Dubin、Nadia Nasser、Ellen E. Codd、Christopher M. Flores、Scott L. Dax

  DOI：10.1016/j.bmcl.2007.09.036

  日期：2007.11

  We report on a series of alpha-substituted-beta-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described. (C) 2007 Elsevier Ltd. All rights reserved.