n-Butyl-methyl-phenyl-phosphin | 36050-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: n-Butyl-methyl-phenyl-phosphin
• 英文别名: butylmethylphenylphosphine；phenylmethylbutylphosphine；n-Butylmethylphenylphosphin；Butyl(methyl)phenylphosphane；butyl-methyl-phenylphosphane
• CAS: 36050-91-6；36850-51-8；36850-52-9
• 化学式: C₁₁H₁₇P
• 分子量: 180.23
• InChiKey: GHSJQOGVLZRRPF-UHFFFAOYSA-N

物化性质

• 沸点：
  67-75 °C(Press: 0.1 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  叠氮基三甲基硅烷 、 n-Butyl-methyl-phenyl-phosphin 反应 1.0h， 以88%的产率得到butyl-methyl-phenyl-trimethylsilylimino-λ5-phosphane
  参考文献：
  名称：

  Wolfsberger, Werner, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1988, vol. 43, # 3, p. 295 - 298

  摘要：

  DOI：
• 作为产物：
  描述：

  Benzyl-n-butyl-methyl-phenyl-phosphoniumbromid 在 sodium amalgam 作用下， 以 甲醇 为溶剂， 反应 0.75h， 以85%的产率得到n-Butyl-methyl-phenyl-phosphin
  参考文献：
  名称：

  Horner, Leopold; Dickerhof, Karlheinz, Phosphorus and Sulfur and the Related Elements, 1983, vol. 15, p. 213 - 218

  摘要：

  DOI：

文献信息

• Highly Atom-Economic One-Pot Formation of Three Different C−P Bonds:  General Synthesis of Acyclic Tertiary Phosphine Sulfides
  作者：Graziano Baccolini、Carla Boga、Marzia Mazzacurati

  DOI：10.1021/jo0502145

  日期：2005.6.1

  4−5 min, was treated with an equimolar amount of R3MgBr, giving the asymmetric phosphine PR1R2R3 in 45% overall yield (75−80% yield when R1 = R2 and 85−90% yield when R1 = R2 = R3) and the byproduct 6 in 90% yield. The treatment of 6 with PCl3 quantitatively regenerates the starting reagent 1. Treatment of the phosphines with elemental sulfur gave the corresponding sulfides.

  苯并噻二磷1与R 1 MgBr和R 2 MgBr的等摩尔混合物反应生成中间体A '，仅在4-5分钟后，用等摩尔量的R 3 MgBr处理中间体A ' ，得到不对称膦PR 1 R 2 R 3占总产率的45％（当R 1 = R 2时产率为75-80％，当R 1 = R 2 = R 3时产率为85-90％），副产物6的产率为90％。用PCl 3处理6可定量再生起始试剂1。用元素硫处理膦，得到相应的硫化物。
• Stereospecific synthesis of diastereoisomerically pure (–)-(R_p)-O-menthyl methylphenylphosphinite and ethylphenylphosphinite: key intermediates in synthesis of chiral tertiary phosphines
  作者：Jan OmelaṄczuk、Wiesława Perlikowska、Marian Mikołajczyk

  DOI：10.1039/c39800000024

  日期：——

  The reaction of the diastereoisomerically pure (–)-(RP)-O-menthyl methylphenylphosphinite (9) and (–)-(RP)-O-menthyl ethylphenylphosphinite (2) with organolithium reagents has been found to give chiral tertiary phosphines (10) and (11) with a very high optical purity.

  （ - ） - （的非对映异构纯的反应- [R P）-O-methylphenylphosphinite（9）和（ - ） - （- [R P） - ø -薄荷基ethylphenylphosphinite（2）与有机锂试剂，已经发现，得到手性叔膦（10）和（11）具有非常高的光学纯度。
• Efficient asymmetric synthesis of optically pure tertiary mono and diphosphine ligands
  作者：S. Juge、M. Stephan、J.A. Laffitte、J.P. Genet

  DOI：10.1016/s0040-4039(00)97063-1

  日期：1990.1

  afford regio and stereoselectively the corresponding aminophosphine complexes . Acid methanolysis of leads to the phosphinite borane complexes which are used for the preparation of the mono and diphosphine boranes , , and subsequently the corresponding phosphines , alter decomplexation with Et2NH. The preparation of (+) and (−)-PAMP , DIPAMP or β-BNPE from the same complex is described.

  由麻黄碱一步制备的氧杂磷杂环丁烷硼烷络合物与烷基和芳基锂化合物反应生成区域和立体选择性的相应氨基膦络合物。酸的甲醇甲醇解反应生成次膦酸酯硼烷配合物，该配合物用于制备单膦酸酯和二膦酸酯硼烷，随后用于制备相应的膦，从而改变与Et 2 NH的分解。描述了从同一复合物中制备（+）和（-）-PAMP ，DIPAMP或β-BNPE 。
• Phenol derivatives
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0163416A2

  公开（公告）日：1985-12-04

  A phenol derivative of the formula wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl- hydroxyindanyl, phenyl-hydroxybenzothienyl or mono- hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R' is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkozyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R' is joined to R2, and wherein X is -CONR2-, CSNR2-, -NR12CO-, -NR12CS-, -NR12CONR2-, -SO2NR2- or -CO-, or, when R1 is not hydrogen, is-NR12COO-,-(PO)R2-, -S-, -SO- or -S02-, wherein R2 is hydrogen or alkyl, or R1 and R2 together form alkylene; wherein R'2 is hydrogen or alkyl, and wherein R22 is hydrogen, cyano or nitro, or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.

  式中的苯酚衍生物 其中 NU 为定义的酚核，包括苯基-羟基萘基；羟基苯基-萘基；苯基-羟基茚基；苯基-羟基苯并噻吩基或单羟基苯基-乙烯基或乙烯基核；其中 A 是亚烷基、亚烯基或亚炔基，可被亚苯基或其他连接物打断，其中 R' 是氢，或烷基、烯基、炔基、环烷基、卤代烷基、烷氧基烷基、卤代烷氧基烷基、芳基或芳烷基，或 R' 与 R2 连接，其中 X 是 -CONR2-、CSNR2-、-NR12CO-、-NR12CS-、-NR12CONR2-、 -SO2NR2-或-CO-，或者，当 R1 不是氢时，是-NR12COO-、-(PO)R2-、-S-、-SO-或-S02-，其中 R2 是氢或烷基，或者 R1 和 R2 一起形成亚烷基；其中 R'2 是氢或烷基，R22 是氢、氰基或硝基，或者适当时是其盐。这些化合物具有抗雌激素活性，可用于治疗激素依赖性乳腺肿瘤或无排卵性不孕症。
• GROUP-15 CATIONIC COMPOUNDS FOR OLEFIN POLYMERIZATION CATALYSTS
  申请人：——

  公开号：US20020111265A1

  公开（公告）日：2002-08-15

  This description addresses fluorinated amine compounds meeting the general formula R′ i ArF-ER 2 , where ArF is a fluoroaryl group, E is nitrogen or phosphorous, each R is independently a C 1 -C 20 hydrocarbyl group, or the two Rs may connect to form an unsubstituted or substituted C 2 -C 20 cycloaliphatic group, R′ is a C 1 -C 20 hydrocarbyl or halogenated hydrocarbyl, and i is 0, 1 or 2. These compounds may be protonated with strong Bronsted acids to form protonated amine compounds that are useful for the preparation of organometallic catalyst-cocatalyst compounds comprising noncoordinating or weakly coordinating anions. The resulting organometallic catalyst-cocatalyst complexes can be effectively used as olefin polymerization catalysts. High number-average molecular weight polymers at high rates of productivity were observed from the use of metallocene catalyst complexes prepared with [N-pentafluorophenyl pyrrolidinium][tetrakis(pentafluorophenyl)borate] of [N-pentafluorophenyl pyrrolidinium][chloride].

  本说明涉及符合通式 R′ 的氟化胺化合物 i ArF-ER 2 其中 ArF 是氟芳基，E 是氮或磷，每个 R 独立地是 C 1 -C 20 烃基，或两个 R 可连接形成未取代或取代的 C 2 -C 20 环脂族基团，R′是一个 C 1 -C 20 烃基或卤代烃基，i 为 0、1 或 2。这些化合物可以用强勃朗斯特酸质子化，形成质子化胺化合物，用于制备包含非配位或弱配位阴离子的有机金属催化剂-催化剂化合物。由此得到的有机金属催化剂-催化剂复合物可有效地用作烯烃聚合催化剂。使用 [N-pentafluorophenyl pyrrolidinium][tetrakis(pentafluorophenyl)borate] of [N-pentafluorophenyl pyrrolidinium][chloride] 制备的茂金属催化剂络合物，可以观察到生产率高的高平均分子量聚合物。