Ethyl 2-benzyl-2-fluoropent-4-enoate | 149194-01-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 2-benzyl-2-fluoropent-4-enoate
• CAS: 149194-01-4
• 化学式: C₁₄H₁₇FO₂
• 分子量: 236.286
• InChiKey: PYASLVPNDLIKOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ethyl 2-benzyl-2-fluoropent-4-enoate 在 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 反应 4.0h， 生成 (2-Sulfanylidenepyridin-1-yl) 2-benzyl-2-fluoropent-4-enoate
  参考文献：
  名称：

  The first general and efficient method for the synthesis of tertiary alkyl fluorides

  摘要：

  The first general and regioselective method for the synthesis of a wide variety of tertiary alkyl fluorides [R1(R2)C(F)R3] has been developed. This novel method involves the successive introduction of three different alkyl groups onto fluorine-bearing prototertiary carbon fragments.

  DOI：

  10.1021/jo00065a005
• 作为产物：
  描述：

  烯丙基三丁基锡 、 ethyl α-fluoro-α-nitro-β-phenylpropionate 在 偶氮二异丁腈 作用下， 以 苯 为溶剂， 反应 3.0h， 生成 Ethyl 2-benzyl-2-fluoropent-4-enoate
  参考文献：
  名称：

  The first general and efficient method for the synthesis of tertiary alkyl fluorides

  摘要：

  The first general and regioselective method for the synthesis of a wide variety of tertiary alkyl fluorides [R1(R2)C(F)R3] has been developed. This novel method involves the successive introduction of three different alkyl groups onto fluorine-bearing prototertiary carbon fragments.

  DOI：

  10.1021/jo00065a005

文献信息

• The first general and efficient method for the synthesis of tertiary alkyl fluorides
  作者：Yoshio Takeuchi、Arihiro Kanada、Shunichi Kawahara、Toru Koizumi

  DOI：10.1021/jo00065a005

  日期：1993.6

  The first general and regioselective method for the synthesis of a wide variety of tertiary alkyl fluorides [R1(R2)C(F)R3] has been developed. This novel method involves the successive introduction of three different alkyl groups onto fluorine-bearing prototertiary carbon fragments.