(5-Amino-1-benzothiophen-2-yl)methanol | 835655-70-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (5-Amino-1-benzothiophen-2-yl)methanol
• CAS: 835655-70-4
• 化学式: C₉H₉NOS
• 分子量: 179.243
• InChiKey: MZBSZSSYQTYHND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  74.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (5-Amino-1-benzothiophen-2-yl)methanol 在 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 3-O-[[18-[(3-ethoxy-3-oxopropanoyl)oxymethyl]-6,17-dithia-1,12-diazahexacyclo[10.10.1.02,10.05,9.013,21.016,20]tricosa-2(10),3,5(9),7,13(21),14,16(20),18-octaen-7-yl]methyl] 1-O-ethyl propanedioate
  参考文献：
  名称：

  Regio/diastereo-controls of the Bingel-type biscyclopropanation of [60]fullerene by using bismalonates with a Tröger base analogue-derived tether

  摘要：

  Four kinds of bismalonates tethered with a Troger base derivative were synthesized and used for the double Bingel reaction of [60]fullerene. the regio/diastereoselectivities of the reaction were highly influenced by the structure of the Troger base derivatives. Heteroaromatic analogues of the Troger base were found to be applicable as the core the the tether. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.11.022
• 作为产物：
  描述：

  5-硝基苯并[b]噻吩-2-羧酸甲酯 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (5-Amino-1-benzothiophen-2-yl)methanol
  参考文献：
  名称：

  Regio/diastereo-controls of the Bingel-type biscyclopropanation of [60]fullerene by using bismalonates with a Tröger base analogue-derived tether

  摘要：

  Four kinds of bismalonates tethered with a Troger base derivative were synthesized and used for the double Bingel reaction of [60]fullerene. the regio/diastereoselectivities of the reaction were highly influenced by the structure of the Troger base derivatives. Heteroaromatic analogues of the Troger base were found to be applicable as the core the the tether. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.11.022

文献信息

• INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEROF
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20220213052A1

  公开（公告）日：2022-07-07

  The present technology is directed to compounds that inhibit of the interaction of RNA-binding proteins with RNA, intermediates thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I).
• Regio/diastereo-controls of the Bingel-type biscyclopropanation of [60]fullerene by using bismalonates with a Tröger base analogue-derived tether
  作者：Yasuhiro Ishida、Hiroshi Ito、Daisuke Mori、Kazuhiko Saigo

  DOI：10.1016/j.tetlet.2004.11.022

  日期：2005.1

  Four kinds of bismalonates tethered with a Troger base derivative were synthesized and used for the double Bingel reaction of [60]fullerene. the regio/diastereoselectivities of the reaction were highly influenced by the structure of the Troger base derivatives. Heteroaromatic analogues of the Troger base were found to be applicable as the core the the tether. (C) 2004 Elsevier Ltd. All rights reserved.