4-[3-[tert-butyl(diphenyl)silyl]oxypropyl]-4-methoxy-3a,6a-dihydro-3H-furo[3,4-c]pyrazol-6-one | 1014987-81-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[3-[tert-butyl(diphenyl)silyl]oxypropyl]-4-methoxy-3a,6a-dihydro-3H-furo[3,4-c]pyrazol-6-one
• CAS: 1014987-81-5
• 化学式: C₂₅H₃₂N₂O₄Si
• 分子量: 452.626
• InChiKey: SOWRACASZMHGMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  69.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[3-[tert-butyl(diphenyl)silyl]oxypropyl]-4-methoxy-3a,6a-dihydro-3H-furo[3,4-c]pyrazol-6-one 以 1,4-二氧六环 为溶剂， 以67%的产率得到5-[3-[Tert-butyl(diphenyl)silyl]oxypropyl]-5-methoxy-4-methylfuran-2-one
  参考文献：
  名称：

  Synthetic studies toward zoapatanol

  摘要：

  The oxepane core of zoapatanol was efficiently synthesized from commercially available 1,2,4-butanetriol, and it was shown to be possible to introduce the angular methyl group at C2' by the reaction of an intermediate butenolide with diazomethane. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.088
• 作为产物：
  描述：

  重氮甲烷 、 5-[3-(tert-butyldiphenylsilyloxy)propyl]-5-methyloxy-5H-furan-2-one 以 乙醚 为溶剂， 以81%的产率得到4-[3-[tert-butyl(diphenyl)silyl]oxypropyl]-4-methoxy-3a,6a-dihydro-3H-furo[3,4-c]pyrazol-6-one
  参考文献：
  名称：

  Synthetic studies toward zoapatanol

  摘要：

  The oxepane core of zoapatanol was efficiently synthesized from commercially available 1,2,4-butanetriol, and it was shown to be possible to introduce the angular methyl group at C2' by the reaction of an intermediate butenolide with diazomethane. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.088

文献信息

• Synthetic studies toward zoapatanol
  作者：Isela García、Manuel Pérez、Pedro Besada、Generosa Gómez、Yagamare Fall

  DOI：10.1016/j.tetlet.2007.12.088

  日期：2008.2

  The oxepane core of zoapatanol was efficiently synthesized from commercially available 1,2,4-butanetriol, and it was shown to be possible to introduce the angular methyl group at C2' by the reaction of an intermediate butenolide with diazomethane. (c) 2007 Elsevier Ltd. All rights reserved.