between 1-formyl-N-substituted-β-carbolines, a terminal alkyne, and a secondary amine allows access to unprecedented polycyclic β-carbolines via sequential A3-coupling and an intramolecular Csp2–Csp2 Friedel–Crafts arylation reaction. The reaction is successful in a dry inert atmosphere only with substrates bearing a methoxy-substituted benzyl group at the indole nitrogen. Conversely, treating 3-aminoindolizino[8
1-甲酰基-N-取代的-β-咔啉,末端
炔烃和仲胺之间的三重协同催化介导的多组分反应允许通过顺序的A 3-偶联和分子内C sp 2 –来获得空前的多环β-咔啉。C sp 2 Friedel-Crafts芳基化反应。该反应仅在干燥的惰性气氛中仅在
吲哚氮带有带有甲氧基取代的苄基的底物时才能成功。相反,在空气中存在H 2 O的情况下,用酸处理3-
氨基
吲哚并[8,7- b ]
吲哚(在A 3偶联后获得)可为制备类似于天然
生物碱的产品提供一般途径。