(3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(methoxymethyloxy)pyrrolidine | 871822-44-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(methoxymethyloxy)pyrrolidine
• 英文别名: (3S,4S)-3,4-bis(methoxymethoxy)-1-(2-phenylmethoxyethyl)pyrrolidine
• CAS: 871822-44-5
• 化学式: C₁₇H₂₇NO₅
• 分子量: 325.405
• InChiKey: LJQSZNUGQMOHGX-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(methoxymethyloxy)pyrrolidine 在 盐酸 作用下， 以 水 为溶剂， 反应 16.0h， 生成 (3S,4S)-1-(2-benzyloxyethyl)pyrrolidine-3,4-diol hydrochloride
  参考文献：
  名称：

  Enantioselective Syntheses of trans-3,4-Difluoropyrrolidines and Investigation of Their Applications in Catalytic Asymmetric Synthesis

  摘要：

  Asymmetric Syntheses of enantiopure trans-3,4-difluoropyrrolidines have been prepared by the introduction of fluorine at both centers in a single operation; asymmetric epoxidations and additions to benzaldehyde were conducted using catalysts whose chirality depends on organofluorine asymmetry.

  DOI：

  10.1021/jo0513414
• 作为产物：
  描述：

  (-)-(2S,3S)-2,3-bis(methoxymethoxy)butane-1,4-diol 在 18-冠醚-6 sodium hydride 、 potassium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 52.0h， 生成 (3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(methoxymethyloxy)pyrrolidine
  参考文献：
  名称：

  Enantioselective Syntheses of trans-3,4-Difluoropyrrolidines and Investigation of Their Applications in Catalytic Asymmetric Synthesis

  摘要：

  Asymmetric Syntheses of enantiopure trans-3,4-difluoropyrrolidines have been prepared by the introduction of fluorine at both centers in a single operation; asymmetric epoxidations and additions to benzaldehyde were conducted using catalysts whose chirality depends on organofluorine asymmetry.

  DOI：

  10.1021/jo0513414

文献信息

• Enantioselective Syntheses of <i>trans</i>-3,4-Difluoropyrrolidines and Investigation of Their Applications in Catalytic Asymmetric Synthesis
  作者：Charles M. Marson、Robert C. Melling

  DOI：10.1021/jo0513414

  日期：2005.11.1

  Asymmetric Syntheses of enantiopure trans-3,4-difluoropyrrolidines have been prepared by the introduction of fluorine at both centers in a single operation; asymmetric epoxidations and additions to benzaldehyde were conducted using catalysts whose chirality depends on organofluorine asymmetry.