Nitrogen bridgehead compounds. 62. Conformational analysis of 6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ones and their methyl derivatives by NMR spectroscopy
On the Regioselectivity of the Gould–Jacobs Reaction: Gas‐Phase Versus Solution‐Phase Thermolysis
作者:Michaela Wernik、Peter E. Hartmann、Gellért Sipos、Ferenc Darvas、A. Daniel Boese、Doris Dallinger、C. Oliver Kappe
DOI:10.1002/ejoc.202001110
日期:2020.12.7
The regioselectivity of the Gould–Jacobs reaction of (pyridyl)aminomethylenemalonates can be controlled either in favor of the kinetic (pyridopyrimidinone) or the thermodynamic (naphthyridinone) product, depending on the position of the substituent in the pyridine moiety and the applied thermolysis technique.