2-(1-phenylcyclopropyl)ethanol | 7306-14-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1-phenylcyclopropyl)ethanol
• CAS: 7306-14-1
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: USRRCOLSPIFBTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(1-phenylcyclopropyl)ethanol 在 三苯基膦 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 53.0h， 生成 2-[2-(1-Phenylcyclopropyl)ethyl]isoindole-1,3-dione
  参考文献：
  名称：

  The intramolecular electron transfer reactions of N-Alkylcyclopropyl phthalimides

  摘要：

  N-Alkylcyclopropyl phthalimides 5 and 6 were photolyzed to afford spiro lactams 17, 18 and 20-24. These products arise via an intramolecular electron transfer reaction between the phthalimide and the phenylcyclopropane portions of the molecule. The resulting radical anion attacks the phenylcyclopropane radical cation which is followed by radical-radical coupling to afford the observed photoadducts. In addition, the isolation of olefin 19 offers additional proof that the attack of the radical anion onto the radical cation is a stepwise process rather than a concerted one. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00108-7
• 作为产物：
  描述：

  γ-亚甲基苯丙醇乙酸酯 在 氢氧化钾 、 copper(l) chloride 、 锌 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 75.0h， 生成 2-(1-phenylcyclopropyl)ethanol
  参考文献：
  名称：

  The intramolecular electron transfer reactions of N-Alkylcyclopropyl phthalimides

  摘要：

  N-Alkylcyclopropyl phthalimides 5 and 6 were photolyzed to afford spiro lactams 17, 18 and 20-24. These products arise via an intramolecular electron transfer reaction between the phthalimide and the phenylcyclopropane portions of the molecule. The resulting radical anion attacks the phenylcyclopropane radical cation which is followed by radical-radical coupling to afford the observed photoadducts. In addition, the isolation of olefin 19 offers additional proof that the attack of the radical anion onto the radical cation is a stepwise process rather than a concerted one. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00108-7

文献信息

• Quinolines useful in treating cardiovascular disease
  申请人：Collini D. Michael

  公开号：US20050131014A1

  公开（公告）日：2005-06-16

  This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.

  本发明提供了式I化合物的用途，它们在治疗或抑制LXR介导的疾病中是有用的。
• Quinolines and pharmaceutical compositions thereof
  申请人：Wyeth

  公开号：US07576215B2

  公开（公告）日：2009-08-18

  This invention provides compounds of formula I that are useful in the treatment or inhibition of LXR mediated diseases.

  本发明提供了I式化合物，可用于治疗或抑制LXR介导的疾病。
• Ring-Size Effects in the Neophyl Rearrangement. VII.¹ The Peroxide-Induced Decarbonylation of (1-Phenylcyclopropyl)- and (1-Phenylcyclobutyl)acetaldehydes
  作者：James W. Wilt、Lester L. Maravetz、Joseph F. Zawadzki

  DOI：10.1021/jo01347a063

  日期：1966.9
• BARTHA E.; ARVAY Z.; RAZUS A. C., REV. ROUM. CHIM., 31,(1986) N 5, 519-524
  作者：BARTHA E.、 ARVAY Z.、 RAZUS A. C.

  DOI：——

  日期：——
• QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE
  申请人：Wyeth, A Corporation of the State of Delaware

  公开号：EP1692111A2

  公开（公告）日：2006-08-23