2,3-dihydroxypropyl elaidate | 25496-72-4

• 物质功能分类: 催化剂及助剂 - 塑料橡胶助剂 - 增塑剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2,3-dihydroxypropyl elaidate
• 英文别名: monoelaidin；Monoolein；2,3-dihydroxypropyl (E)-octadec-9-enoate
• CAS: 25496-72-4
• 化学式: C₂₁H₄₀O₄
• 分子量: 356.546
• InChiKey: RZRNAYUHWVFMIP-MDZDMXLPSA-N

物化性质

• 熔点：
  35-37 °C
• 沸点：
  449.35°C (rough estimate)
• 密度：
  0.96 g/cm3 (25 ºC)
• 溶解度：
  氯仿：50 mg/mL，澄清，无色
• 物理描述：
  DryPowder; Liquid; OtherSolid
• 颜色/状态：
  PLATES FROM ETHANOL
• 气味：
  SWEET
• 味道：
  FATTY TASTE
• 折光率：
  INDEX OF REFRACTION: 1.4626 @ 40 °C/D

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  25
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

毒理性

• 人类毒性摘录

用人红细胞幽灵膜与融合脂质甘油单油酸酯处理增加了膜脂的流动性，而非融合脂质甘油单硬脂酸酯没有效果。

TREATMENT OF HUMAN ERYTHROCYTE GHOST MEMBRANES WITH THE FUSOGENIC LIPID GLYCEROL MONOOLEATE INCREASED THE FLUIDITY OF THE MEMBRANE LIPIDS, BUT THE NONFUSOGENIC LIPID GLYCEROL MONOSTEARATE HAD NO EFFECT.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

如果这些酯类中有任何一种具有显著毒性，那么应该归咎于酸部分，而不是甘油。/甘油酯/

IF ANY OF THESE ESTERS IS SIGNIFICANTLY TOXIC, THE ACID PORTION MUST BE HELD RESPONSIBLE, NOT THE GLYCEROL. /GLYCEROL ESTERS/

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品运输编号：
  NONH for all modes of transport
• WGK Germany：
  1

制备方法与用途

用途

• 用作增稠剂
• 用作表面活性剂、润滑剂及医药原料等
• 非离子表面活性剂，具有乳化、增稠和消泡性能。在日化工业中，可用作生产膏霜类化妆品、液体洗涤香波的乳化剂、增溶剂、遮光剂以及消泡剂；在纺织工业中用作织物整理剂，并可作为颜料研磨添加剂。此外，也可用作消泡剂，具有降粘和抑泡作用。

反应信息

• 作为反应物：
  描述：

  2,3-dihydroxypropyl elaidate 、 十八烷酰氯 在 吡啶 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以11%的产率得到1,2-Distearo-3-elaidin
  参考文献：
  名称：

  含有桉树酸的混合二酸甘油三酸酯的合成及理化特性

  摘要：

  AbstractThe synthesis of symmetrical and asymmetrical palmito‐ and stearo‐elaidic triglycerides (PEP, SES, EPP, PEE, ESS, and SEE, in which P=palmitic, S=stearic, and E=elaidic acid) was undertaken to investigate their polymorphism. The chemical pathways and the purification steps, including crystallization and adsorption chromatography, are described. The different chromatographic analyses (gas‐liquid chromatography: carbon number profile and fatty acid methyl ester profile, and high‐performance liquid chromatography) revealed that the purity of the synthesized products was superior to 99% except for SES (>96%). The thermal behavior, as well as the polymorphism of these triglycerides, has been investigated by means of differential scanning calorimetry and powder X‐ray diffraction spectroscopy at variable temperatures. The six compounds crystallize according to a double chainlength packing. The most stable polymorphic form of palmito‐elaidic triglycerides belongs to the β′ variety, whereas the stearo‐elaidic triglycerides are β stable.

  DOI：

  10.1007/s11746-998-0043-6
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 乙醚 作用下， 生成 2,3-dihydroxypropyl elaidate
  参考文献：
  名称：

  Daubert, Journal of the American Chemical Society, 1944, vol. 66, p. 291

  摘要：

  DOI：

文献信息

• [EN] METHOD OF REDUCING SPOILAGE IN HARVESTED PRODUCE DURING STORAGE AND SHIPPING<br/>[FR] PROCÉDÉ DE RÉDUCTION DE LA DÉTÉRIORATION DE PRODUITS RÉCOLTÉS PENDANT LE STOCKAGE ET L'EXPÉDITION
  申请人：APEEL TECH INC

  公开号：WO2017172951A1

  公开（公告）日：2017-10-05

  Described herein are formulations and methods of reducing spoilage in harvested produce by reducing the rate of water or mass loss, thereby resulting in high quality produce with lower rates of spoilage. The present disclosure provides coatings and methods of coating produce to prevent moisture loss from produce during storage and shipment of the produce. This in turn allows the produce to be shipped and stored at lower relative humidity (e.g., lower than industry standards for shipment and storage, or lower than about 90% relative humidity), which can help delay the growth of biotic stressors such as fungi, bacteria, viruses, and/or pests.

  本文描述了一种减少收获农产品变质的配方和方法，通过减少水分或质量的流失速率，从而获得质量高、变质率低的农产品。本文提供了覆盖物和覆盖农产品的方法，以防止农产品在储存和运输过程中失去水分。这反过来允许农产品在较低的相对湿度下运输和储存（例如低于行业运输和储存标准或低于约90%的相对湿度），这可以延迟生物胁迫因素（如真菌、细菌、病毒和/或害虫）的生长。
• PLANT EXTRACT COMPOSITIONS FOR FORMING PROTECTIVE COATINGS
  申请人：Apeel Technology, Inc.

  公开号：EP3649860A1

  公开（公告）日：2020-05-13

  Described herein are methods of preparing cutin-derived monomers, oligomers, or combinations thereof from cutin-containing plant matter. The methods can include heating the cutin-derived plant matter in a solvent at elevated temperature and pressure. In some preferred embodiments, the methods can be carried out without the use of additional acidic or basic species.

  本文描述了从含有角叉菜胶的植物物质中制备角叉菜胶衍生单体、低聚物或其组合的方法。这些方法可包括在溶剂中以升高的温度和压力加热植物角质素衍生物质。在一些优选的实施方案中，这些方法可以在不使用额外的酸性或碱性物质的情况下进行。
• SOLID SOLUTION COMPOSITIONS
  申请人：InFirst Healthcare Limited

  公开号：EP3795141A1

  公开（公告）日：2021-03-24

  The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a severe pain in an individual using such pharmaceutical compositions.

  本说明书公开了药物组合物、制备此类药物组合物的方法以及使用此类药物组合物治疗个人剧烈疼痛的方法和用途。
• Solid solution compositions and use in chronic inflammation
  申请人：Infirst Healthcare Limited

  公开号：US10154975B2

  公开（公告）日：2018-12-18

  The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.

  本说明书公开了药物组合物、制备此类药物组合物的方法以及使用此类药物组合物治疗慢性炎症和/或炎症性疾病的方法和用途。
• Compositions and methods for treating chronic inflammation and inflammatory diseases
  申请人：Infirst Healthcare Limited

  公开号：US10155042B2

  公开（公告）日：2018-12-18

  The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.

  本说明书公开了药物组合物、制备此类药物组合物的方法以及使用此类药物组合物治疗慢性炎症和/或炎症性疾病的方法和用途。

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