1-(3-Azidopropoxy)-4-nitrobenzene | 864528-96-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Azidopropoxy)-4-nitrobenzene
• CAS: 864528-96-1
• 化学式: C₉H₁₀N₄O₃
• 分子量: 222.203
• InChiKey: PASLPORPTCLRJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3-Azidopropoxy)-4-nitrobenzene 在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 生成 4-(3-amino-propoxy)-aniline
  参考文献：
  名称：

  Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors

  摘要：

  We designed a series of anilino-indoylmaleimides based on structural elements from literature JAK3 inhibitors 3 and 4, and our lead 5. These new compounds were tested as inhibitors of JAKs 1, 2 and 3 and TYK2 for therapeutic intervention in rheumatoid arthritis (RA). Our requirements, based on current scientific rationale for optimum efficacy against RA with reduced side effects, was for potent, mixed JAK1 and 3 inhibition, and selectivity over JAK2. Our efforts yielded a potent JAK3 inhibitor 11d and its eutomer 11e. These compounds were highly selective for inhibition of JAK3 over JAK2 and TYK. The compounds displayed only modest JAK1 inhibition. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.001
• 作为产物：
  描述：

  1-(3-溴丙氧基)-4-硝基苯 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-(3-Azidopropoxy)-4-nitrobenzene
  参考文献：
  名称：

  新型咪唑衍生物的结构动力学和抗生物膜筛选，探讨其对铜绿假单胞菌的抗生物膜抑制机制

  摘要：

  生物膜的形成仍然是铜绿假单胞菌（革兰氏阴性菌）产生耐药性的普遍机制，以其在医院、呼吸机相关疾病中的主要作用而闻名。

  DOI：

  10.1080/07391102.2024.2317983

文献信息

• Copper-catalyzed <i>in situ</i> oxidative-coupling for one-pot synthesis of 5-aryl-1,4-disubstituted 1,2,3-triazoles under mild conditions
  作者：Chao Wang、Qianqian Li、Shilei Wang、Gongming Zhu、Anlian Zhu、Lingjun Li

  DOI：10.1039/d1ra06827j

  日期：——

  A new reaction system with CuCl as catalyst, TEA as base and O2/chloramine-T as oxidant was developed for one-pot in situ oxidative-coupling to synthesize 5-aryl-1,4-disubstituted 1,2,3-triazoles in this paper. A variety of 5-arylated-1,2,3-triazole compounds could be efficiently prepared directly from the readily accessible organic azides, terminal alkynes and arylboronic acids. Advantages of the

  建立了以CuCl为催化剂、TEA为碱、O 2 /氯胺-T为氧化剂的一锅法原位氧化偶联合成5-芳基-1,4-二取代1,2,3-三唑的新反应体系。在本文中。各种5-芳基化-1,2,3-三唑化合物可以直接从容易获得的有机叠氮化物、末端炔烃和芳基硼酸有效地制备。该方法的优点包括使用低成本催化剂、清洁氧化剂、毒性较小的添加剂和低反应温度。重要的是，由于避免了苛刻的强碱性试剂和高温，所提出的方法可以为从设计的结构复杂的带有天然产物基序的炔基或叠氮化物供体多组分合成5-芳基-1,2,3-三唑提供温和的条件和敏感的官能团。
• Macrocyclic Compounds And Methods Of Making And Using The Same
  申请人：Farmer J. Jay

  公开号：US20080045585A1

  公开（公告）日：2008-02-21

  The present invention provides macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

  本发明提供了一种用作治疗剂的大环化合物。更具体地说，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。
• Triazole compounds and methods of making and using the same
  申请人：Bhattacharjee Ashoke

  公开号：US20100016955A1

  公开（公告）日：2010-01-21

  The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

  本发明提供了三唑大环化合物，作为治疗剂使用。更具体地说，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。
• MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Farmer Jay J.

  公开号：US20120252747A1

  公开（公告）日：2012-10-04

  The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R 1 , R 2 , R 3 , D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.

  本发明提供了通式为的大环化合物，可用作治疗剂，或其药学上可接受的盐、酯、N-氧化物或前药，其中T、R1、R2、R3、D、E、F和G如本文所定义。更具体地，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。
• Triazole Compounds and Methods of Making and Using the Same
  申请人：Rib-X Pharmaceuticals, Inc.

  公开号：US20140094422A1

  公开（公告）日：2014-04-03

  The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. These compounds are represented by the following formula (I): wherein R 1 , R 2 , etc. are defined as in Claim 1.

  本发明提供了三唑大环化合物，可用作治疗剂。更具体地说，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。这些化合物由以下式（I）表示：其中，R1，R2等如权利要求书1中所定义。