dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate | 247170-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate
• 英文别名: benzyl N-[2-[2-aminoethyl-[2-(phenylmethoxycarbonylamino)ethyl]amino]ethyl]carbamate
• CAS: 247170-99-6
• 化学式: C₂₂H₃₀N₄O₄
• 分子量: 414.505
• InChiKey: JSCNYVMGOWIPML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate 、 benzyl tert-butyl (6-oxohexane-1,5-diyl)(S)-dicarbamate 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 benzyl tert-butyl (7-(2-(((benzyloxy)carbonyl)amino)ethyl)-3-oxo-1-phenyl-2-oxa-4,7,10-triazahexadec-10-ene-12,16-diyl)(S)-dicarbamate
  参考文献：
  名称：

  Eu(III) Complexes of Functionalized Octadentate 1-Hydroxypyridin-2-ones: Stability, Bioconjugation, and Luminescence Resonance Energy Transfer Studies

  摘要：

  The synthesis, stability, and photophysical properties of several Eu(III) complexes featuring the 1-hydroxypyridin-2-one (1,2-HOPO) chelate group in tetradentate and octadentate ligands are reported. These complexes pair highly efficient emission with exceptional stabilities (pEu similar to 20.7-21.8) in aqueous solution at pH 7.4. Further analysis of their solution behavior has shown the observed luminescence intensity is significantly diminished below about pH similar to 6 because of an apparent quenching mechanism involving protonation of the amine backbones. Nonetheless, under biologically relevant conditions, these complexes are promising candidates for applications in Homogeneous Time-Resolved Fluorescence (HTRF) assays and synthetic methodology to prepare derivatives with either a terminal amine or a carboxylate group suitable for bioconjugation has been developed. Lastly, we have demonstrated the use of these compounds as the energy donor in a Luminescence Resonance Energy Transfer (LRET) biological assay format.

  DOI：

  10.1021/ic101133w
• 作为产物：
  描述：

  dibenzyl tert-butyl(nitrilotris(ethane-2,1-diyl))tricarbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以65%的产率得到dibenzyl {[(2-aminoethyl)azanediyl]bis(ethane-2,1-diyl)}dicarbamate
  参考文献：
  名称：

  WO2006/55437

  摘要：

  公开号：

文献信息

• Complexes and Ligands
  申请人：The General Hospital Corporation

  公开号：US20220025254A1

  公开（公告）日：2022-01-27

  The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.

  本申请提供了配体和包括这些配体的荧光或发光配合物。
• Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition
  作者：Ulrike Kauscher、Bart Jan Ravoo

  DOI：10.3762/bjoc.8.175

  日期：——

  well as one or two mannose units. The carbohydrate-lectin interaction in this artificial, self-assembled glycocalyx was monitored in an agglutination assay by the increase of optical density at 400 nm. It was found that there is a close relation between the carbohydrate density at the cyclodextrin vesicle surface and the multivalent interaction with ConA, and the most efficient interaction (i.e., fastest

  环糊精囊泡是生物细胞膜的通用模型，因为它们提供了双层膜，可以通过主客体与功能性客体分子的相互作用轻松修饰。在本文中，我们研究了凝集素伴刀豆球蛋白 A (ConA) 与环糊精囊泡的多价相互作用，环糊精囊泡装饰有带有一个、两个或三个金刚烷单元以及一个或两个甘露糖单元的甘露糖-金刚烷缀合物。在凝集试验中，通过增加 400 nm 处的光密度来监测这种人工自组装糖萼中的碳水化合物-凝集素相互作用。发现环糊精囊泡表面的碳水化合物密度与与 ConA 的多价相互作用之间存在密切关系，并且最有效的相互作用（即，
• MACROCYCLES
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150157746A1

  公开（公告）日：2015-06-11

  The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.

  这项发明提供了在螯合金属离子中特别是放射性核素中有用的大环化合物，以提供金属离子配合物。该发明还提供了使用这些化合物和配合物的方法，例如在治疗和诊断应用中。
• LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
  申请人：Raymond Kenneth N.

  公开号：US20080213917A1

  公开（公告）日：2008-09-04

  The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

  本发明提供了一种新的大环化合物类别，以及由金属（例如镧系金属）离子和本发明中化合物形成的配合物。首选的配合物在水介质中表现出高稳定性以及高量子产率的镧系离子发光特性，无需使用次级活化剂。首选化合物在其大环结构中包含羟基异苯酰胺基团，并以惊人的低非特异性结合多种多肽（如抗体和蛋白质）以及高动力学稳定性为特征。这些特征使它们与已知的开放结构配体有所区别。
• WO2008/63721
  申请人：——

  公开号：——

  公开（公告）日：——