methyl 4-(3-aminobenzoylamino)butanoate | 842949-91-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 4-(3-aminobenzoylamino)butanoate
• 英文别名: methyl 4-[(3-aminobenzoyl)amino]butanoate
• CAS: 842949-91-1
• 化学式: C₁₂H₁₆N₂O₃
• mdl: MFCD13319865
• 分子量: 236.271
• InChiKey: NEDGZCPOEZWHQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 4-(3-aminobenzoylamino)butanoate 、 水杨酰氯 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  AMINO ACID DIAMIDES IN NON ALPHA POSITION USEFUL AS ADJUVANTS FOR THE ADMINISTRATION OF ACTIVE BIOLOGICAL AGENTS

  摘要：

  公开号：

  EP1652836B1

文献信息

• AMINO ACID DIAMIDES IN NON ALPHA POSITION WHICH ARE USEFUL AS ADJUVANTS FOR ADMINISTRATION OF BIOLOGICAL ACTIVE AGENTS
  申请人：Sarkis Mardiguian Jean

  公开号：US20070191302A1

  公开（公告）日：2007-08-16

  Amino acid diamides in non α position of formula (1), wherein R 1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO 2 , OH, OCH 3 alone or associated and R 2 is selected from the group consisting of functional groups H, alkyl, halogen, NO 2 , OH, OCH 3 , which are useful as adjuvants for the administration of biological active agents, as well as pharmaceutical compositions containing these diamides of formula (1) and the use thereof for the manufacture of antithrombotic medications and for the manufacture of a medication for the treatment of a disease selected from amongst the group consisting of inflammation, cancer and allergy.

  公式（1）中非α位的氨基酸二酰胺，其中R1从以下官能团组中选择，包括烷基，卤素，NO2，OH，OCH3单独或联合；R2从以下官能团组中选择，包括H，烷基，卤素，NO2，OH，OCH3，它们可用作生物活性剂的辅助剂。此外，还包括含有公式（1）的这些二酰胺的制药组合物及其用于制造抗血栓药物和治疗炎症，癌症和过敏等疾病的药物的用途。
• Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents
  申请人：Laboratorios Farmaceuticos Rovi, S.A.

  公开号：US07462735B2

  公开（公告）日：2008-12-09

  Amino acid diamides in non α position of formula (1), wherein R1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO2, OH, OCH3 alone or associated and R2 is selected from the group consisting of functional groups H, alkyl, halogen, NO2, OH, OCH3, which are useful as adjuvants for the administration of biological active agents, as well as pharmaceutical compositions containing these diamides of formula (1) and the use thereof for the manufacture of antithrombotic medications and for the manufacture of a medication for the treatment of a disease selected from amongst the group consisting of inflammation, cancer and allergy.

  公式（1）中非α位的氨基酸二酰胺，其中R1从以下官能团组中选择，包括仅为或结合的烷基，卤素，NO2，OH，OCH3，而R2从以下官能团组中选择，包括H，烷基，卤素，NO2，OH，OCH3，这些二酰胺可用作生物活性剂的辅料，以及包含公式（1）的这些二酰胺的制药组合物，以及其用于制造抗血栓药物和治疗炎症，癌症和过敏等疾病的药物的用途。
• US7462735B2
  申请人：——

  公开号：US7462735B2

  公开（公告）日：2008-12-09
• AMINO ACID DIAMIDES IN NON ALPHA POSITION USEFUL AS ADJUVANTS FOR THE ADMINISTRATION OF ACTIVE BIOLOGICAL AGENTS
  申请人：LABORATORIOS FARMACEUTICOS ROVI, S.A.

  公开号：EP1652836B1

  公开（公告）日：2007-07-18