dimethyl 2,3-dimethylglutarate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dimethyl 2,3-dimethylglutarate
• 英文别名: Dimethyl 2,3-dimethylpentanedioate
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: PUKYTVNHRCDJFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl (E)-5-methoxy-2,3-dimethyl-5-trimethylsilyloxypent-4-enoate 生成 dimethyl 2,3-dimethylglutarate
  参考文献：
  名称：

  KAWAI, MOTOMITSU;ONAKA, MAKOTO;IZUMI, YUSUKE, BULL. CHEM. SOC. JAP., 61,(1988) N 6, 2157-2164

  摘要：

  DOI：

文献信息

• Clay Montmorillonite: An Efficient, Heterogeneous Catalyst for Michael Reactions of Silyl Ketene Acetals and Silyl Enol Ethers with α,β-Unsaturated Carbonyl Compounds
  作者：Motomitsu Kawai、Makoto Onaka、Yusuke Izumi

  DOI：10.1246/bcsj.61.2157

  日期：1988.6

  The Michael addition of silyl ketene acetals to α,β-unsaturated esters (enoates) is investigated. The reaction is catalyzed by clay montmorillonite (solid acid) most effectively among various, homo...

  研究了甲硅烷基乙烯酮缩醛与 α,β-不饱和酯（烯酸酯）的迈克尔加成。该反应由粘土蒙脱石（固体酸）催化，在各种均质...
• Enantioselective Michael reactions. Stereoselective addition of enolates of phenmenthol esters to crotonates
  作者：E.J. Corey、Richard T. Peterson

  DOI：10.1016/s0040-4039(01)80843-1

  日期：——

  A method is described for enantioselective synthesis which is based on the stereoselective Michael addition of phenmenthol enolates such as 5 to -crotonate esters. A stereomechanistic rationale is presented.

  描述了一种用于对映选择性合成的方法，该方法基于苯酚薄荷醇烯酸酯（例如5-丁烯酸酯）的立体选择性迈克尔加成。提出了立体力学原理。
• PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS
  申请人：Array BioPharma Inc.

  公开号：US20150099881A1

  公开（公告）日：2015-04-09

  The invention provides new processes for making and purifying hydroxylated cyclopenta[d]pyrimidine compounds, which are useful for the treatment of diseases such as cancer as AKT protein kinase inhibitors, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.

  本发明提供了制备和纯化羟基化环戊二氮杂嘧啶化合物的新工艺，该化合物可作为AKT蛋白激酶抑制剂用于治疗癌症等疾病，包括(S)-2-(4-氯苯基)-1-(4-((5R,7R)-7-羟基-5-甲基-6,7-二氢-5H-环戊二氮杂嘧啶-4-基)哌嗪-1-基)-3-(异丙基氨基)丙酮。
• KAWAI, MOTOMITSU;ONAKA, MAKOTO;IZUMI, YUSUKE, BULL. CHEM. SOC. JAP., 61,(1988) N 6, 2157-2164
  作者：KAWAI, MOTOMITSU、ONAKA, MAKOTO、IZUMI, YUSUKE

  DOI：——

  日期：——
• US9309204B2
  申请人：——

  公开号：US9309204B2

  公开（公告）日：2016-04-12