tetrakis-(8-amino-6-aza-2-oxa-5-oxooctyl)methane | 221898-80-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetrakis-(8-amino-6-aza-2-oxa-5-oxooctyl)methane
• 英文别名: tetrakis(8-amino-6-aza-2-oxa-5-oxooctyl)methane；N-(2-aminoethyl)-3-[3-[3-(2-aminoethylamino)-3-oxopropoxy]-2,2-bis[[3-(2-aminoethylamino)-3-oxopropoxy]methyl]propoxy]propanamide
• CAS: 221898-80-2
• 化学式: C₂₅H₅₂N₈O₈
• 分子量: 592.737
• InChiKey: OFKUAGPTUWMPSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7
• 重原子数：
  41
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  257
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  tetrakis-(8-amino-6-aza-2-oxa-5-oxooctyl)methane 、 5'-O-dimethoxytrityldeoxythymidine-3'-p-nitrophenylsuccinate 以 吡啶 为溶剂， 反应 16.0h， 以45%的产率得到tetrakis-<6,9-diaza-13-<5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxythymidine-3'-O-yl>-2-oxa-5,10,13-trioxotridecyl>methane
  参考文献：
  名称：

  Synthesis of new liquid phase carriers for use in large scale oligonucleotide synthesis in solution

  摘要：

  The synthesis of multifunctional symmetric primary amines 4 and 8 and the covalent binding of 5'-O-dimethoxytrityl-deoxynucleoside derivatives to their amino groups (compound 5 and 9) is described. Different strategies for dedimethoxytritylation including the use of strong acidic ion exchangers or protic acids and modified silica gels and/or gel permeation chromatography are developed. The resulting liquid phase carriers 6 and 10 are suitable for large scale oligonucleotide synthesis in solution using phosphoamidites and gel permeation chromatography for fast isolation of intermediates. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00058-7
• 作为产物：
  描述：

  四(氰基乙氧基甲基)甲烷 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 97.0h， 生成 tetrakis-(8-amino-6-aza-2-oxa-5-oxooctyl)methane
  参考文献：
  名称：

  Synthesis of new liquid phase carriers for use in large scale oligonucleotide synthesis in solution

  摘要：

  The synthesis of multifunctional symmetric primary amines 4 and 8 and the covalent binding of 5'-O-dimethoxytrityl-deoxynucleoside derivatives to their amino groups (compound 5 and 9) is described. Different strategies for dedimethoxytritylation including the use of strong acidic ion exchangers or protic acids and modified silica gels and/or gel permeation chromatography are developed. The resulting liquid phase carriers 6 and 10 are suitable for large scale oligonucleotide synthesis in solution using phosphoamidites and gel permeation chromatography for fast isolation of intermediates. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00058-7

文献信息

• Solution Phase Biopolymer Synthesis
  申请人：——

  公开号：US20020007048A1

  公开（公告）日：2002-01-17

  Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X 1 ) n , where Sp is a highly symmetrical moiety such that all X 1 groups are equivalent. X 1 is a functional group that is suitable for biopolymer synthesis, including OH, SH, NH 2 , COOH and the like. Biopolymers that may be produced using the methods provided include oligonucleotides, peptides, protein nucleic acids (PNAs) and oligosaccharides. Analogs of the biopolymers may also be prepared using the methods.

  提供了多功能液相载体（LPCs）及其在生物聚合物制备中的使用方法。这些LPCs是高度对称的化合物，具有超过两个用于生物聚合物合成的连接点。这些LPCs的化学式为Sp（X1）n，其中Sp是一种高度对称的基团，使得所有X1基团是等效的。X1是适用于生物聚合物合成的功能基团，包括OH、SH、NH2、COOH等。使用所提供的方法可以制备的生物聚合物包括寡核苷酸、肽、蛋白质核酸（PNAs）和寡糖。还可以使用这些方法制备生物聚合物的类似物。
• SOLUTION PHASE BIOPOLYMER SYNTHESIS
  申请人：——

  公开号：US20020016451A1

  公开（公告）日：2002-02-07

  Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X 1 ) n , where Sp is a highly symmetrical moiety such that all X 1 groups are equivalent. X 1 is a functional group that is suitable for biopolymer synthesis, including OH, SH, NH 2 , COOH and the like. Biopolymers that may be produced using the methods provided include oligonucleotides, peptides, protein nucleic acids (PNAs) and oligosaccharides. Analogs of the biopolymers may also be prepared using the methods.

  本发明提供了多功能液相载体（LPCs）及其用于制备生物聚合物的方法。LPCs是高度对称的化合物，具有超过两个生物聚合物合成点的附着点。LPCs的化学式为Sp（X1）n，其中Sp是高度对称的基团，使得所有X1基团等效。X1是适用于生物聚合物合成的功能基团，包括OH，SH，NH2，COOH等。使用提供的方法可以制备的生物聚合物包括寡核苷酸，肽，蛋白质核酸（PNAs）和寡糖。也可以使用这些方法制备生物聚合物的类似物。
• US7038103B2
  申请人：——

  公开号：US7038103B2

  公开（公告）日：2006-05-02
• US7094943B2
  申请人：——

  公开号：US7094943B2

  公开（公告）日：2006-08-22
• [EN] SOLUTION PHASE BIOPOLYMER SYNTHESIS<br/>[FR] SYNTHESE DE BIOPOLYMERES EN PHASE DE SOLUTION
  申请人：——

  公开号：WO1999055718A2

  公开（公告）日：1999-11-04

  [EN] Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X<1>)n, where Sp is a highly symmetrical moiety such that all X<1> groups are equivalent. X<1> is a functional group that is suitable for biopolymer synthesis, including OH, SH, NH2, COOH and the like. Biopolymers that may be produced using the methods provided include oligonucleotides, peptides, protein nucleic acids (PNAs) and oligosaccharides. Analogs of the biopolymers may also be prepared using the methods.
  [FR] L'invention concerne des supports en phase liquide (LPC) multifonctionnels et des procédés d'utilisation des LPC en vue de la préparation de biopolymères. Les LPC sont des composés hautement symétriques qui possèdent plus de deux points de fixation pour une synthèse de biopolymères. Les LPC sont représentés par la formule Sp(X<1>)n, dans laquelle Sp est une fraction hautement symétrique telle que tous les groupes X<1> sont équivalents. X<1> est un groupe fonctionnel convenant pour une synthèse de biopolymères, qui comprend OH, SH, NH2, COOH et analogue. Les biopolymères qui peuvent être produits à l'aide des procédés comprennent notamment des oligonucléotides, des peptides, des acides nucléiques protéiniques (PNA) et des oligosaccharides. Des analogues des biopolymères peuvent également être préparés à l'aide des procédés.