1-ethoxy-2-n-propoxybenzene | 228395-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-ethoxy-2-n-propoxybenzene
• 英文别名: 1-ethoxy-2-propoxy benzene；1-ethoxy-2-propoxybenzene
• CAS: 228395-55-9
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: FPYVISMMJWFRIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  邻乙氧基苯酚 、 1-碘代丙烷 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 1-ethoxy-2-n-propoxybenzene
  参考文献：
  名称：

  Electron donors

  摘要：

  一种聚合至少一种烯烃的方法，包括将该烯烃与一个催化剂组合物接触，该催化剂组合物包括： 1）一个前催化剂组合物，包括含有镁和钛的组分以及结构为以下式子的电子给体化合物： 其中R1为乙氧基，R2为具有一到十个碳原子的烷氧基，R3-R6分别为氢、烃基、羟基烃基、硝基、硅基或卤素； 2）一个协同催化剂；和可选的 3）一个选择性控制剂。

  公开号：

  US06399837B1

文献信息

• [EN] LIBRARIES OF HETEROARYL-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] BIBLIOTHÈQUES DE COMPOSÉS MACROCYCLIQUES CONTENANT HÉTÉROARYLE ET PROCÉDÉS POUR LEUR FABRICATION ET LEUR UTILISATION
  申请人：CYCLENIUM PHARMA INC

  公开号：WO2017049383A1

  公开（公告）日：2017-03-30

  The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.

  本公开涉及新型大环化合物及其库，其中包含对药物发现工作有用的含杂环芳基团的化合物。本公开还涉及制备这些化合物和库的方法，以及使用这些库的方法，例如在高通量筛选中使用。特别是，这些库可用于评估现有和新鉴定的药理学相关靶点的生物活性，包括G蛋白偶联受体、核受体、酶、离子通道、转运蛋白、转录因子、蛋白质相互作用和核酸-蛋白质相互作用。因此，这些库可应用于寻找用于治疗和预防各种医疗状况的新药物。
• METHODS AND COMPOSITIONS FOR CONTROL OF GYPSY MOTHS, Lymanria dispar
  申请人：Plettner Erika

  公开号：US20100190865A1

  公开（公告）日：2010-07-29

  The invention provides in part dialkoxybenzene and eugenol compounds for controlling infestation by a Lymantria dispar , and methods thereof. The compounds include a compound of Formula I: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; R2 may be at positions 2, 3 or 4 and may be H, methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; and R3 may be optionally present at positions 2, 3 and 4, and is allyl; with the provisos that when R2 is at position 2, R3 if present is at position 3, or when R2 is at to position 3, R3 if present is at positions 2 or 4, or when R2 is at position 4, R3 if present is at position 2; or of Formula II: where R1 may be methyl, ethyl, propyl, n-butyl, isopentyl (3-methylbutyl) or allyl; or mixtures thereof.

  该发明部分提供了用于控制以及方法的苯基二甲氧基苯和丁香酚化合物对Lymantria dispar的侵害。这些化合物包括式I的化合物：其中R1可以是甲基、乙基、丙基、正丁基、异戊基（3-甲基丁基）或烯丙基；R2可以在2、3或4位，可以为H、甲基、乙基、丙基、正丁基、异戊基（3-甲基丁基）或烯丙基；R3可以选择性地存在于2、3和4位，为烯丙基；但要注意的是，当R2在2位时，如果R3存在，则在3位，或者当R2在3位时，如果R3存在，则在2或4位，或者当R2在4位时，如果R3存在，则在2位；或者式II的化合物：其中R1可以是甲基、乙基、丙基、正丁基、异戊基（3-甲基丁基）或烯丙基；或它们的混合物。
• COMPOUND AND COLORED RESIN COMPOSITION
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20210002487A1

  公开（公告）日：2021-01-07

  An object of the present invention is to provide a novel squarylium dye that can achieve an equivalent chromaticity value of even a colored resin composition having a low content of the squarylium dye as compared with a colored resin composition comprising a conventional squarylium dye. The present invention provides a compound represented by the formula (I) wherein R 4 to R 4 each independently represent a hydrogen atom or the like; R 5 to R 8 each independently represent a hydrogen atom or the like; R 9 and R 10 each independently represent a monovalent saturated hydrocarbon group having 1 to 20 carbon atoms or the like; R 11 and R 12 each independently represent a halogen atom or an alkyl halide group having 1 to 6 carbon atoms; and m1 and m2 each independently represent an integer of 1 to 5.

  本发明的一个目的是提供一种新型的方苯基染料，即使与含有传统方苯基染料的着色树脂组合相比，也可以实现具有低含量方苯基染料的着色树脂组合的等效色度值。本发明提供了一个由式（I）表示的化合物，其中R4到R4各自独立地表示氢原子或类似物；R5到R8各自独立地表示氢原子或类似物；R9和R10各自独立地表示具有1到20个碳原子的一价饱和碳氢基团或类似物；R11和R12各自独立地表示卤素原子或具有1到6个碳原子的烷基卤素基团；m1和m2各自独立地表示1到5的整数。
• Process for the preparation of tamsulosin and intermediates thereof
  申请人：Mendes Zita

  公开号：US20090234154A1

  公开（公告）日：2009-09-17

  A process for producing tamsulosin of formula I and pharmaceutically acceptable addition salts, thereof comprises the steps of: a) Reacting compound R,R-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amine of formula II or a salt thereof with chlorosulfonic acid with or without an organic solvent, to obtain compound R,R-2-methoxy-5-[2-(1-phenyl-ethylamino)-propyl]-benzenesulfonic acid of formula III b) Hydrogenolysis of compound R,R-2-methoxy-5-[2-(1-phenyl-ethylamino)-propyl]-benzenesulfonic acid of formula III or a salt thereof carried out in an alcohol in the presence of a palladium catalyst using hydrogen or a source of hydrogen, to obtain compound R-(−)-5-(2-amino-propyl)-2-methoxy-benzenesulfonic acid of formula IV c) Reacting primary amine R-(−)-5-(2-amino-propyl)-2-methoxy-benzenesulfonic acid of formula IV, or a salt thereof, with a compound of formula V wherein X represents an halogen atom selected from the group consisting of Cl; Br and I, to obtain 5-(2R)-2-[2-(2-ethoxy-phenoxy)-ethylamino]-propyl}-2-methoxy-benzenesulfonic acid compound of formula VI d) Reacting compound of formula VI with an halogenating agent, to obtain the corresponding sulfonylchloride of formula VII. e) Reacting compound VII with ammonia to obtain compound I.

  生产公式I的盐酸他唑嗪及其药用可接受盐的方法包括以下步骤： a)将公式II化合物R，R-[2-(4-甲氧基苯基)-1-甲基乙基]-(1-苯基乙基)-胺或其盐与氯磺酸在有机溶剂的存在下或无机溶剂的缺席下反应，得到公式III的R，R-2-甲氧基-5-[2-(1-苯基乙基氨基)-丙基]-苯磺酸化合物。 b)在存在钯催化剂的情况下，使用氢气或氢源，在醇的存在下对公式III的R，R-2-甲氧基-5-[2-(1-苯基乙基氨基)-丙基]-苯磺酸化合物或其盐进行氢解反应，得到公式IV的R-(−)-5-(2-氨基丙基)-2-甲氧基苯磺酸化合物。 c)将公式IV的主要氨基R-(−)-5-(2-氨基丙基)-2-甲氧基苯磺酸化合物或其盐与公式V的化合物反应，其中X代表从Cl、Br和I组成的卤素原子，以得到公式VI的5-(2R)-2-[2-(2-乙氧基苯氧基)-乙基氨基]-丙基}-2-甲氧基苯磺酸化合物。 d)将公式VI的化合物与卤化试剂反应，得到相应的公式VII的磺酰氯。 e)将公式VII的化合物与氨反应，得到公式I的化合物。
• Method for Identifying Ziegler-Natta Cocatalysts
  申请人：Campbell E. Richard

  公开号：US20070276102A1

  公开（公告）日：2007-11-29

  A method for identifying a catalyst composition for use in the heterogeneous Ziegler-Natta addition polymerization of an olefin monomer, said catalyst composition comprising a procatalyst comprising a magnesium and titanium containing procatalyst and a cocatalyst said method comprising: a) providing a library comprising at least one procatalyst compound, b) forming a catalyst composition library by contacting the member of said procatalyst library with one or more cocatalysts and contacting the resulting mixture with an olefin monomer under olefin polymerization conditions thereby causing the polymerization reaction to take place, c) measuring at least one variable of interest during the polymerization, and d) selecting the catalyst composition of interest by reference to said measured variable.

  一种用于在杂化Ziegler-Natta加成聚合中识别催化剂组合物的方法，该催化剂组合物包括一种含有镁和钛的前催化剂和一种助催化剂，该方法包括：a）提供包括至少一种前催化剂化合物的库，b）通过将前催化剂库的成员与一种或多种助催化剂接触，并在烯烃聚合条件下将所得混合物与烯烃单体接触，从而引起聚合反应，形成催化剂组合物库，c）在聚合过程中测量至少一个感兴趣的变量，d）通过参考所测量的变量选择感兴趣的催化剂组合物。