2-Amino-5-chloro-N-p-tolyl-benzamide | 30686-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-5-chloro-N-p-tolyl-benzamide
• 英文别名: 2-amino-5-chloro-N-(4-methylphenyl)benzamide
• CAS: 30686-42-1
• 化学式: C₁₄H₁₃ClN₂O
• mdl: MFCD02120001
• 分子量: 260.723
• InChiKey: QGOWUYMDDLANDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Amino-5-chloro-N-p-tolyl-benzamide 在 dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 以84%的产率得到4-Chloro-2-[(4-methylanilino)methyl]aniline
  参考文献：
  名称：

  Unraveling the Role of Alkyl F on CH−π Interactions and Uncovering the Tipping Point for Fluorophobicity

  摘要：

  Although fluorine often plays an influential role in molecular recognition, little is known about the effect of aliphatic fluorine on the CH-pi interaction in solution. A series of molecular balances were synthesized that contain fluorinated and nonfluorinated alkyl groups. Our findings indicate that fluorine's polarizing ability does enhance CH-7r binding and depends on molecular orientation. Surprisingly, when the terminal end of the alkyl group is completely fluorinated, the balance tips toward fluorophobicity and assumes an unusual constrained conformation.

  DOI：

  10.1021/acs.joc.5b01072
• 作为产物：
  描述：

  5-氯靛红酸酐 、 乙烷,三氯氟- 以 1,4-二氧六环 、 乙醇 为溶剂， 以65%的产率得到2-Amino-5-chloro-N-p-tolyl-benzamide
  参考文献：
  名称：

  Unraveling the Role of Alkyl F on CH−π Interactions and Uncovering the Tipping Point for Fluorophobicity

  摘要：

  Although fluorine often plays an influential role in molecular recognition, little is known about the effect of aliphatic fluorine on the CH-pi interaction in solution. A series of molecular balances were synthesized that contain fluorinated and nonfluorinated alkyl groups. Our findings indicate that fluorine's polarizing ability does enhance CH-7r binding and depends on molecular orientation. Surprisingly, when the terminal end of the alkyl group is completely fluorinated, the balance tips toward fluorophobicity and assumes an unusual constrained conformation.

  DOI：

  10.1021/acs.joc.5b01072

文献信息

• Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides
  作者：Liangliang Luo、Hongyan Li、Jinxin Liu、Yuan Zhou、Lin Dong、You-Cai Xiao、Fen-Er Chen

  DOI：10.1039/d0ra04636a

  日期：——

  A highly efficient TMSCl-mediated addition of N-nucleophiles to isocyanides has been achieved.

  一种高效的TMSCl介导的N-亲核试剂加成到异氰酸酯的方法已经实现。
• Improved synthesis of symmetrical and unsymmetrical 5,11-methanodibenzo[b,f][1,5]diazocines. Readily available nanoscale structural units
  作者：Thomas H. Webb、Craig S. Wilcox

  DOI：10.1021/jo00288a067

  日期：1990.1
• XALDEEVA V. A.; KONSHIN M. E., REDKOLLEGIYA ZH. ZHZV. VYSSH. UCHEB. ZAVEDENIJ . XIMIYA I XIM. TEXNOL. ZH+
  作者：XALDEEVA V. A.、 KONSHIN M. E.

  DOI：——

  日期：——
• Unraveling the Role of Alkyl F on CH−π Interactions and Uncovering the Tipping Point for Fluorophobicity
  作者：Mark R. Ams、Michael Fields、Timothy Grabnic、Benjamin G. Janesko、Matthias Zeller、Rose Sheridan、Amanda Shay

  DOI：10.1021/acs.joc.5b01072

  日期：2015.8.7

  Although fluorine often plays an influential role in molecular recognition, little is known about the effect of aliphatic fluorine on the CH-pi interaction in solution. A series of molecular balances were synthesized that contain fluorinated and nonfluorinated alkyl groups. Our findings indicate that fluorine's polarizing ability does enhance CH-7r binding and depends on molecular orientation. Surprisingly, when the terminal end of the alkyl group is completely fluorinated, the balance tips toward fluorophobicity and assumes an unusual constrained conformation.