4-[3-(tert-butyl-dimethyl-silanoxy)-2-(tert-butyl-dimethyl-silanoxymethyl)-propoxy]-2-methoxy-5-thien-2-yl-benzaldehyde | 552845-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[3-(tert-butyl-dimethyl-silanoxy)-2-(tert-butyl-dimethyl-silanoxymethyl)-propoxy]-2-methoxy-5-thien-2-yl-benzaldehyde
• 英文别名: 4-[3-(TERT-BUTYLDIMETHYLSILANYLOXY)-2-(TERT-BUTYLDIMETHYLSILANYLOXYMETHYL)PROPOXY]-2-METHOXY-5-THIOPHEN-2-YL-BENZALDEHYDE；4-[3-[Tert-butyl(dimethyl)silyl]oxy-2-[[tert-butyl(dimethyl)silyl]oxymethyl]propoxy]-2-methoxy-5-thiophen-2-ylbenzaldehyde
• CAS: 552845-93-9
• 化学式: C₂₈H₄₆O₅SSi₂
• 分子量: 550.907
• InChiKey: DOINUZDKXXSJJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.27
• 重原子数：
  36
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  82.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[3-(tert-butyl-dimethyl-silanoxy)-2-(tert-butyl-dimethyl-silanoxymethyl)-propoxy]-2-methoxy-5-thien-2-yl-benzaldehyde 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 21915.0h， 以90%的产率得到4-(3-hydroxy-2-hydroxymethyl-propoxy)-2-methoxy-5-thiophen-2-yl-benzaldehyde
  参考文献：
  名称：

  [EN] PROCESS OF MAKING CHALCONE DERIVATIVES
  [FR] PROCEDE DE FABRICATION DE DERIVES DE CHALCONE

  摘要：

  公开号：

  WO2004056727A3
• 作为产物：
  描述：

  3-(tert-butyldimethylsilanyloxy)-2-(tert-butyldimethylsilanyloxymethyl)propan-1-ol 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 4-[3-(tert-butyl-dimethyl-silanoxy)-2-(tert-butyl-dimethyl-silanoxymethyl)-propoxy]-2-methoxy-5-thien-2-yl-benzaldehyde
  参考文献：
  名称：

  Carboxylated, Heteroaryl-Substituted Chalcones as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases

  摘要：

  Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression. Correlations between lipophilicity determined by calculated logP values and inhibitory efficacy were observed among structurally similar compounds of the series. Various substituents were found to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the right range of lipophilicity. The chalcone alpha,beta-unsaturated ketone moiety seemed to be the pharmacophore required for inhibition of VCAM-1 expression. Compound 19 showed significant antiinflammatory effects in a mouse model of allergic inflammation, indicating that this series of compounds might have therapeutic value for human asthma and other inflammatory disorders.

  DOI：

  10.1021/jm0614230