3-O-benzoyl-6,6-dibromo-5,6-dideoxy-1,2-O-isopropylidene-D-allofuranose | 1038779-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-O-benzoyl-6,6-dibromo-5,6-dideoxy-1,2-O-isopropylidene-D-allofuranose
• 英文别名: [(3aR,5R,6R,6aR)-5-(2,2-dibromoethenyl)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-6-yl] benzoate
• CAS: 1038779-70-2
• 化学式: C₁₆H₁₆Br₂O₅
• 分子量: 448.108
• InChiKey: UCERTYHDJWIKDN-BPGGGUHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  bromo(4-ethoxy-4-oxobutyl)zinc 、 3-O-benzoyl-6,6-dibromo-5,6-dideoxy-1,2-O-isopropylidene-D-allofuranose 在 四(三苯基膦)钯 作用下， 以 四氢呋喃 、 苯 为溶剂， 以54%的产率得到ethyl 3-O-benzoyl-5,6,7,8,9-pentadeoxy-6-[3-(ethoxycarbonyl)propyl]-1,2-O-isopropylidene-α-D-ribo-dec-5-enofuranuronate
  参考文献：
  名称：

  S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit

  摘要：

  Treatment of the protected ribose or xylose 5-aldehyde with sulfonyl-stabilized fluorophosphonate gave (fluoro)vinyl sulfones. Stannyldesulfonylation followed by iododestannylation afforded 5,6-dideoxy-6-fluoro-6-iodo-D-ribo or xylo-hex-5-enofuranoses. Coupling of the hexenofuranoses with alkylzinc bromides gave 10-carbon ribosyl- and xylosylhomocysteine analogues incorporating a fluoroalkene. The fluoroalkenyl and alkenyl analogues were evaluated for inhibition of Bacillus subtilis S-ribosyl-homocysteinase (LuxS). One of the compounds, 3,5,6-trideoxy-6-fluoro-D-erythro-hex-5-enofuranose, acted as a competitive inhibitor of moderate potency (K(I) = 96 mu M). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.028
• 作为产物：
  描述：

  (+)-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-allofuranos-3-yl benzoate 在 高碘酸 、 三苯基膦 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 2.0h， 生成 3-O-benzoyl-6,6-dibromo-5,6-dideoxy-1,2-O-isopropylidene-D-allofuranose
  参考文献：
  名称：

  S-腺苷-L-高半胱氨酸水解酶的失活和具有5'，5'，6'，6'-四脱氢-6'-脱氧-6'-卤代人腺苷类似物（衍生自腺苷的4'-卤代乙炔类似物）的抗病毒活性。

  摘要：

  用硝酸银和N-碘代琥珀酰亚胺（NIS）处理受保护的9-（5，6-二脱氧-β-D-核糖基-己基-5-ynofuranosyl）腺嘌呤衍生物并脱保护，得到6'-碘炔基核苷类似物3c。3-O-苯甲酰基-5,6-二脱氧-1，2-O-异亚丙基-α-D-核糖-六-5-烯呋喃糖的卤代反应生成6-卤代炔糖，将其转化为异头的1,2-二-邻乙酰基衍生物，并与6-N-苯甲酰腺嘌呤偶联。将这些中间体脱保护，得到6'-氯3a，6'-溴3b和6'-碘3c炔属核苷类似物。碘化合物3c似乎通过I型（“辅因子耗竭”）机制使S-腺苷-L-高半胱氨酸水解酶失活，因为观察到酶结合的NAD +完全还原为NADH，并且未检测到腺嘌呤或碘离子的释放。相比之下，将酶与氯3a或溴3b类似物一起温育会导致Cl-或Br-和Ade的释放，以及E-NAD +部分还原为E-NADH。化合物3a，3b和3c抑制牛痘病毒，水泡性口炎病毒，副流感3病毒和

  DOI：

  10.1021/jm980163m

文献信息

• Developing an efficient route to the synthesis of nucleoside 1-alkynylphosphonates
  作者：Maïa Meurillon、Franck Gallier、Suzanne Peyrottes、Christian Périgaud

  DOI：10.1016/j.tet.2009.05.064

  日期：2009.8

  A series of ribonucleoside 1-alkynylphosphonates have been synthesized using a palladium-catalyzed phosphonylation of terminal 1,1-dibromo-1-alkene nucleosidic derivatives and high selectivity for product distribution was observed during this step. Both nucleosidic and osidic pathways were explored and the corresponding optimization study is reported herein. (C) 2009 Elsevier Ltd. All rights reserved.
• Inactivation of <i>S</i>-Adenosyl-<scp>l</scp>-homocysteine Hydrolase and Antiviral Activity with 5‘,5‘,6‘,6‘-Tetradehydro-6‘-deoxy-6‘-halohomoadenosine Analogues (4‘-Haloacetylene Analogues Derived from Adenosine)
  作者：Morris J. Robins、Stanislaw F. Wnuk、Xiaoda Yang、Chong-Sheng Yuan、Ronald T. Borchardt、Jan Balzarini、Erik De Clercq

  DOI：10.1021/jm980163m

  日期：1998.9.1

  intermediates were deprotected to give the 6'-chloro 3a, 6'-bromo 3b, and 6'-iodo 3c acetylenic nucleoside analogues. Iodo compound 3c appears to inactivate S-adenosyl-L-homocysteine hydrolase by a type I ("cofactor depletion") mechanism since complete reduction of enzyme-bound NAD+ to NADH was observed and no release of adenine or iodide ion was detected. In contrast, incubation of the enzyme with the chloro 3a

  用硝酸银和N-碘代琥珀酰亚胺（NIS）处理受保护的9-（5，6-二脱氧-β-D-核糖基-己基-5-ynofuranosyl）腺嘌呤衍生物并脱保护，得到6'-碘炔基核苷类似物3c。3-O-苯甲酰基-5,6-二脱氧-1，2-O-异亚丙基-α-D-核糖-六-5-烯呋喃糖的卤代反应生成6-卤代炔糖，将其转化为异头的1,2-二-邻乙酰基衍生物，并与6-N-苯甲酰腺嘌呤偶联。将这些中间体脱保护，得到6'-氯3a，6'-溴3b和6'-碘3c炔属核苷类似物。碘化合物3c似乎通过I型（“辅因子耗竭”）机制使S-腺苷-L-高半胱氨酸水解酶失活，因为观察到酶结合的NAD +完全还原为NADH，并且未检测到腺嘌呤或碘离子的释放。相比之下，将酶与氯3a或溴3b类似物一起温育会导致Cl-或Br-和Ade的释放，以及E-NAD +部分还原为E-NADH。化合物3a，3b和3c抑制牛痘病毒，水泡性口炎病毒，副流感3病毒和
• S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit
  作者：Stanislaw F. Wnuk、Jennifer Lalama、Craig A. Garmendia、Jenay Robert、Jinge Zhu、Dehua Pei

  DOI：10.1016/j.bmc.2008.03.028

  日期：2008.5

  Treatment of the protected ribose or xylose 5-aldehyde with sulfonyl-stabilized fluorophosphonate gave (fluoro)vinyl sulfones. Stannyldesulfonylation followed by iododestannylation afforded 5,6-dideoxy-6-fluoro-6-iodo-D-ribo or xylo-hex-5-enofuranoses. Coupling of the hexenofuranoses with alkylzinc bromides gave 10-carbon ribosyl- and xylosylhomocysteine analogues incorporating a fluoroalkene. The fluoroalkenyl and alkenyl analogues were evaluated for inhibition of Bacillus subtilis S-ribosyl-homocysteinase (LuxS). One of the compounds, 3,5,6-trideoxy-6-fluoro-D-erythro-hex-5-enofuranose, acted as a competitive inhibitor of moderate potency (K(I) = 96 mu M). (C) 2008 Elsevier Ltd. All rights reserved.