2-甲基-2-苯基戊-3-酮 | 828-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲基-2-苯基戊-3-酮
• 英文名称: 2-methyl-2-phenylpentan-3-one
• 英文别名: 2-Methyl-2-phenyl-pentan-3-on
• CAS: 828-60-4
• 化学式: C₁₂H₁₆O
• mdl: MFCD17288540
• 分子量: 176.258
• InChiKey: KEMOSTULIVJDHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-甲基-2-苯基戊-3-酮 在 sodium hydroxide 、 溴 作用下， 生成 alpha,alpha-二甲基苯乙酸
  参考文献：
  名称：

  Zalesskaya,T.E.; Remizova,T.B., Journal of general chemistry of the USSR, 1964, vol. 34, p. 3215 - 3219

  摘要：

  DOI：
• 作为产物：
  描述：

  2-methyl-2-phenylpentan-3-ol 在 碳酸氢钠 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 0.33h， 以1.23 g的产率得到2-甲基-2-苯基戊-3-酮
  参考文献：
  名称：

  乙醇与硝基反应生成硝基

  摘要：

  在60°C下，用氢氧化钠的甲醇溶液处理在α位具有2-硝基苯基的酮。在这些条件下，源自酮的烯醇化物在分子内与硝基反应形成各种硝酮。其他实验结果，包括意外分离出副产物N-羟基吲哚酮，导致了通过α-羟基酮发生的拟议反应机理。所得的硝基酮与烯烃进行分子间和分子内的1，3-偶极环加成反应，得到多环异恶唑烷。

  DOI：

  10.1021/acs.orglett.1c00603

文献信息

• [EN] NOVEL BENZIMIDAZOLE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE
  申请人：ENANTA PHARM INC

  公开号：WO2013052369A1

  公开（公告）日：2013-04-11

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明揭示了式（I）的化合物，或其药学上可接受的盐、酯或前药：其抑制RNA含量的病毒，特别是丙型肝炎病毒（HCV）。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及包含上述化合物的制药组合物，用于治疗患有HCV感染的受试者。本发明还涉及通过给受试者注射包含本发明化合物的制药组合物来治疗HCV感染的方法。
• Hepatitis C Virus Inhibitors
  申请人：Belema Makonen

  公开号：US20110237636A1

  公开（公告）日：2011-09-29

  This disclosure concerns novel compounds of Formula (I) as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C virus (HCV). Thus, the disclosure also concerns a method of treating HCV related diseases or conditions by use of these novel compounds or a composition comprising such novel compounds.

  本公开涉及式(I)中定义的新化合物及含有这些新化合物的组合物。这些化合物是有用的抗病毒剂，特别是在抑制由丙型肝炎病毒（HCV）编码的NS5A蛋白的功能方面。因此，本公开还涉及使用这些新化合物或含有这些新化合物的组合物治疗HCV相关疾病或状况的方法。
• Improved thermoplastic elastomers
  申请人：EDISON POLYMER INNOVATION CORPORATION ( EPIC)

  公开号：EP0346919A2

  公开（公告）日：1989-12-20

  A polymerization process for preparing a block copolymer characterized by the following steps carried out at a temperature below about -40°C in the order recited, (1) polymerizing isobutylene in a reaction mixture including said isobutylene, a titanium halide, a mixed solvent, and an initiator compound selected from the group consisting of cumyl ester compounds and cumyl ether compounds, to form a first polymer, wherein when said temperature is from about -40°C to -90°C, or when the initiator compound has more than one ester or ether linkage, said reaction mixture is formed by first combining said mixed solvent, said initiator, said isobutylene, and a moisture scavenger, and then adding said titanium halide, and wherein said mixed solvent comprises a mixture of a non-halogenated hydrocarbon solvent with a halogenated hydrocarbon solvent, and (2) after polymerizing said isobutylene, adding a conjugated diene monomer of the general formula in which R₁ is selected from a hydrocarbyl group containing from one to twelve carbon atoms, and R₂, R₃, and R₄, are selected from hydrogen or a hydrocarbyl group containing from one to twelve carbon atoms, to said reaction mixture and polymerizing said diene to form a triblock copolymer in which said first polymer comprises a midblock, and the polymerized diene forms the endblocks of said triblock copolymer, or a multi-block copolymer in which said first polymer comprises an elastomeric segment flanked by blocks of the polymerized diene containing partially cyclized segments.

  一种制备嵌段共聚物的聚合工艺，其特征在于按所述顺序在低于约-40℃的温度下进行以下步骤，(1)在包括所述异丁烯、卤化钛、混合溶剂和选自由积酯化合物和积醚化合物组成的组的引发剂化合物的反应混合物中聚合异丁烯，以形成第一种聚合物，其中当所述温度为约-40℃至-90℃时、或当引发剂化合物具有一个以上的酯或醚连接时，所述反应混合物的形成方法是：首先将所述混合溶剂、所述引发剂、所述异丁烯和除湿剂混合，然后加入所述卤化钛，其中所述混合溶剂包括非卤代烃溶剂与卤代烃溶剂的混合物，以及 (2) 在聚合所述异丁烯后，加入通式为的共轭二烯单体 其中 R₁ 选自含有 1 至 12 个碳原子的烃基，R₂、R₃ 和 R₄ 选自氢或含有 1 至 12 个碳原子的烃基、聚合的二烯形成所述三嵌段共聚物的端嵌段，或多嵌段共聚物，其中所述第一聚合物包括弹性段，两侧是含有部分环化段的聚合二烯嵌段。
• Method for preparing polyolefins containing vinylidene groups using azole compounds
  申请人：Chevron Oronite Company LLC

  公开号：EP1803741A1

  公开（公告）日：2007-07-04

  Disclosed is a method for preparing polyolefins containing vinylidine end groups from quasiliving carbocationically terminated polyolefin polymers by contacting the quasiliving carbocationically terminated polymer with a suitable azole quenching agent and substituted derivatives thereof.

  本发明公开了一种方法，通过将准羰基端聚烯烃聚合物与合适的唑类淬火剂及其取代衍生物接触，从准羰基端聚烯烃聚合物中制备含有乙烯烷端基团的聚烯烃。
• Method for preparing polyolefins containing vinylidene end groups using nonaromatic heterocyclic compounds
  申请人：Chevron Oronite Company LLC

  公开号：EP1803748A1

  公开（公告）日：2007-07-04

  Disclosed is a method for preparing polyolefins containing vinylidine end groups from quasiliving carbocationically terminated polyolefin polymers by contacting the quasiliving carbocationically terminated polymer with a suitable nonaromatic heterocyclic ring quenching agent and substituted derivatives thereof.

  本发明公开了一种方法，通过将准碳基终止聚烯烃聚合物与合适的非芳香杂环环淬火剂及其取代衍生物接触，从准碳基终止聚烯烃聚合物中制备含有乙烯烷端基的聚烯烃。