2-benzyl-1,1-dichlorocyclopropane | 939-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyl-1,1-dichlorocyclopropane
• 英文别名: Cyclopropane, 1,1-dichloro-2-(phenylmethyl)；(2,2-dichlorocyclopropyl)methylbenzene
• CAS: 939-78-6
• 化学式: C₁₀H₁₀Cl₂
• mdl: MFCD00778547
• 分子量: 201.095
• InChiKey: DGWQDTVVILBZOP-UHFFFAOYSA-N

物化性质

• 沸点：
  115-116 °C(Press: 10 Torr)
• 密度：
  1.24±0.1 g/cm3(Predicted)
• 保留指数：
  1365

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-benzyl-1,1-dichlorocyclopropane 在 二氯二茂钛 二异丁基氢化铝 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.0h， 生成 环丙基苯甲烷
  参考文献：
  名称：

  Efficient method for the synthesis of monohalocyclopropanes by reduction of gem-dihalocyclopropanes with i-Bu2AlH in the presence of Ti and Zr complexes

  摘要：

  We have investigated the reductive dehalogenation reaction of alkyl and aryl substituted gemdihalocyclopropanes with diisobutyl aluminum hydride in the presence of catalytic amounts of titanium and zirconium complexes. As a result we propose a general method for the synthesis of substituted monohalocyclopropanes and cyclopropanes of various structures. We have also studied the stereochemistry of the reduction.

  DOI：

  10.1007/bf00961692
• 作为产物：
  描述：

  烯丙苯 、 氯仿 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 生成 2-benzyl-1,1-dichlorocyclopropane
  参考文献：
  名称：

  Tishchenko,I.G. et al., Journal of Organic Chemistry USSR (English Translation), 1975, vol. 11, p. 579 - 582

  摘要：

  DOI：

文献信息

• Stereoselective reduction of gem-dichlorocyclopropanes to cis-monochlorocyclopropanes by lithium aluminum hydride in the presence of titanium and zirconium complexes
  作者：U. M. Dzhemilev、R. L. Gaisin、A. A. Turchin、G. A. Tolstikov

  DOI：10.1007/bf00960415

  日期：1991.9

  A versatile stereoselective method is presented for the synthesis of cis-monochlorocyclopropanes by the reduction of dehalogenated alkyl- and aryl-gem-dichlorocyclopropanes in the presence of catalytic quantities of titanium and zirconium complexes.
• New system for nitrosation of alkyl-substituted gem-dichlorocyclopropanes
  作者：Oksana B. Bondarenko、Anna Yu. Gavrilova、Dilovar S. Murodov、Nikolai V. Zyk、Nikolai S. Zefirov

  DOI：10.1016/j.mencom.2011.07.004

  日期：2011.7

  Treatment of alkyl-substituted gem-dichlorocyclopropanes with NOCl-AlCl(3) system affords alkyl-5-chloroisoxazoles.
• Tishchenko,I.G. et al., Journal of Organic Chemistry USSR (English Translation), 1975, vol. 11, p. 579 - 582
  作者：Tishchenko,I.G. et al.

  DOI：——

  日期：——
• Nitration of 2-Aryl-1,1-dihalocyclopropanes Containing Methyl or Phenyl Group
  作者：Lee-Huey Lin、Shaw-Tao Lin、Hucy-Ju Yang

  DOI：10.1002/jccs.199800032

  日期：1998.2

  AbstractGem‐dihalocyclopropanes bearing a phenyl group and an additional group were nitrated by using nitric acid in a sulfuric acid matrix. The products from the nitration of aryl rings are major. The presence of a methyl group on the C(2) position of the cyclopropane ring leads to the isoxazoline from nitration at the C(1)‐position instead of that from nitration at the C(2)‐position.
• Mochalov; Trofimova; Fedotov, Russian Journal of Organic Chemistry, 1996, vol. 32, # 6, p. 817 - 825
  作者：Mochalov、Trofimova、Fedotov、Shabarov、Zefirov

  DOI：——

  日期：——