2,6-二氨基吡啶-3,5-二甲醛 | 36986-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二氨基吡啶-3,5-二甲醛
• 英文名称: 2,6-diamino-pyridine-3,5-dicarbaldehyde
• 英文别名: 2,6-Diaminopyridine-3,5-dicarbaldehyde
• CAS: 36986-81-9
• 化学式: C₇H₇N₃O₂
• 分子量: 165.151
• InChiKey: UGSOJDVFVVLHPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,6-二氨基吡啶-3,5-二甲醛 在 盐酸 、 氢氧化钾 、 硝酸 、 magnesium 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 水 为溶剂， 生成 4-[2,8-Bis(4-methoxyphenyl)pyrido[2,3-b][1,8]naphthyridin-5-yl]phenol
  参考文献：
  名称：

  Dendrimers with anthyridine-based hydrogen-bonding units at their cores: Synthesis, complexation and self-assembly studies

  摘要：

  Generation 1-4 Frechet-type dendritic bromides were covalently linked to anthyridine (6) to give ''sticky'' dendrons 7a-7d. The binding constants of 1:1 complexes between 7 and benzamidinium salt 8 were measured to assess their ability to act as building blocks for self-assembly. A 2:1 complex of 7 and pentamidine 9 formed in 1% CD3CN/CDCl3 indicating the utility of these compounds for constructing larger dendritic assemblies. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)01222-7
• 作为产物：
  描述：

  2,6-二氨基吡啶 、 氯仿 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以4%的产率得到2,6-二氨基吡啶-3,5-二甲醛
  参考文献：
  名称：

  Convenient synthesis of 2-amino-1,8-naphthyridines, building blocks for host-guest and self-assembling systems

  摘要：

  Application of the Reimer-Tiemann reaction to 2,6-diaminopyridine afforded a 26% yield of 2,6-diaminopyridine-3-carboxaldehyde (4) and a small amount (4%) of 2,6-diaminopyridine-3,5-dicarboxaldehyde. Alternatively, conversion of 2,6-diaminopyridine to 2,6-bis(pivaloylamino)pyridine (6), directed lithiation with n-butyllithium, treatment with N-formylmorpholine, and hydrolysis produced 4 in 67% overall yield. The Friedlander condensation of 4 with a variety of activated and unactivated ketones afforded 2-amino-1,8-naphthyridines and bis(2-amino-1,8-naphthyridines) in moderate to good yields, providing a convenient synthesis of useful building blocks for new host-guest and self-assembling systems.

  DOI：

  10.1021/jo00076a021

文献信息

• CALUWE P.; MAJEWICZ T. G., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 21, 3410-3413
  作者：CALUWE P.、 MAJEWICZ T. G.

  DOI：——

  日期：——