6-[N-(6-Maleimidocaproyl)]caproic acid nhs | 1337538-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 6-[N-(6-Maleimidocaproyl)]caproic acid nhs
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 6-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]hexanoate
• CAS: 1337538-62-1
• 化学式: C₂₀H₂₇N₃O₇
• 分子量: 421.45
• InChiKey: ORYSOTITDJRHCL-UHFFFAOYSA-N

物化性质

• 熔点：
  72-74 °C(Solv: ethyl ether (60-29-7))
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-(6-氨基己酰氨基)己酸 在 三氟乙酸酐 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 6-[N-(6-Maleimidocaproyl)]caproic acid nhs
  参考文献：
  名称：

  In Situ Formation of N-Trifluoroacetoxy Succinimide (TFA-NHS): One-Pot Formation of Succinimidyl Esters, N-Trifluoroacetyl Amino Acid Succinimidyl Esters, and N-Maleoyl Amino Acid Succinimidyl Esters

  摘要：

  A method for the in situ formation of N-trifluoroacetoxy succinimide (TFA-NHS) and its application in the formation of succinimidyl esters is presented. The developed method provides N-trifluoroacetyl and N-maleoyl amino acid succinimidyl esters from a variety of amino acids using a one-pot, high-yielding protocol. Investigations into the formation of an N-maleoyl amino acid succinimidyl ester supported the proposal of a revised reaction mechanism, and contributed to the optimization of the reaction conditions.

  DOI：

  10.1021/jo201686e

文献信息

• Living Copolymer-Protein/Peptide Hybrids for Biomedical Applications
  申请人：Raja Krishnaswami

  公开号：US20110262991A1

  公开（公告）日：2011-10-27

  Water soluble polymers having formula I: Y-(L 1 ) ni -(C(O)) n2 —(R 1 ) n3 —R 2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.

  具有I式的水溶性聚合物：Y-(L1)ni-(C（O）)n2—（R1）n3—R2被声明。这些聚合物可以包含多个水溶性、免疫原性降低的基团和多个活性基团。这些聚合物可以与具有多达十二个氨基酸的蛋白质或肽连接。
• AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
  申请人：MENDELSOHN Brian Alan

  公开号：US20150218220A1

  公开（公告）日：2015-08-06

  The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.
• US9242010B2
  申请人：——

  公开号：US9242010B2

  公开（公告）日：2016-01-26
• [EN] LIVING COPOLYMER PROTEIN/PEPTIDE HYBRIDS FOR BIOMEDICAL APPLICATIONS<br/>[FR] HYBRIDES DE COPOLYMÈRES PROTÉINE/PEPTIDE VIVANTS DESTINÉS À DES APPLICATIONS BIOMÉDICALES
  申请人：UNIV CITY

  公开号：WO2009140683A1

  公开（公告）日：2009-11-19

  Water soluble polymers having formula I: Y-(L1)ni-(C(O))n2-(R1)n3-R2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.
• In Situ Formation of <i>N</i>-Trifluoroacetoxy Succinimide (TFA-NHS): One-Pot Formation of Succinimidyl Esters, <i>N</i>-Trifluoroacetyl Amino Acid Succinimidyl Esters, and <i>N</i>-Maleoyl Amino Acid Succinimidyl Esters
  作者：Nicholas M. Leonard、Jarmila Brunckova

  DOI：10.1021/jo201686e

  日期：2011.11.4

  A method for the in situ formation of N-trifluoroacetoxy succinimide (TFA-NHS) and its application in the formation of succinimidyl esters is presented. The developed method provides N-trifluoroacetyl and N-maleoyl amino acid succinimidyl esters from a variety of amino acids using a one-pot, high-yielding protocol. Investigations into the formation of an N-maleoyl amino acid succinimidyl ester supported the proposal of a revised reaction mechanism, and contributed to the optimization of the reaction conditions.