3-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yloxoethylidene)-1,3-dihydro-2H-indol-2-one | 1219602-23-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yloxoethylidene)-1,3-dihydro-2H-indol-2-one
• CAS: 1219602-23-9
• 化学式: C₂₆H₁₇N₃O₃
• 分子量: 419.439
• InChiKey: YLZOLSPTPQSJHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  32.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yloxoethylidene)-1,3-dihydro-2H-indol-2-one 在 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 反应 8.0h， 以93%的产率得到3'-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yl)-1',4'-dihydrospiro[2-oxo-1H-indol-3,5'-pyrazole]
  参考文献：
  名称：

  Synthesis of Some New Pyridazinylspirohetarylindoles and Hetarylpyridazine Derivatives

  摘要：

  Condensation of 4-acetyl-5,6-diphenylpyridazine-3(2H)-one (1) with 1H-indol-2,3-dione afforded the biheterocyclic enone 2. Interaction of 2 with some bifunctional nitrogen nucleophiles and dimedone yielded some novel pyridazinyl spirohetarylindoles 3-6. The reaction of 3-chloropyridazine derivative 7 with some heterocyclic compounds having vicinal amino and cyano groups gave hetarylaminopyridazines 9 and 13. Treatment of acetylpyridazinone I with arylidenecyanoacetate and arylidenemalononitrile afforded pyridylpyridazines 16 and 19, respectively. The effect of some active methylene compounds and thioacetamide on biheterocyclic enone 22 was also studied.

  DOI：

  10.3987/com-09-11845
• 作为产物：
  描述：

  4-acetyl-5,6-diphenyl-3(2H)-pyridazinone 、 靛红 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以58.5%的产率得到3-(3-oxo-5,6-diphenyl-2H-pyridazin-4-yloxoethylidene)-1,3-dihydro-2H-indol-2-one
  参考文献：
  名称：

  Synthesis of Some New Pyridazinylspirohetarylindoles and Hetarylpyridazine Derivatives

  摘要：

  Condensation of 4-acetyl-5,6-diphenylpyridazine-3(2H)-one (1) with 1H-indol-2,3-dione afforded the biheterocyclic enone 2. Interaction of 2 with some bifunctional nitrogen nucleophiles and dimedone yielded some novel pyridazinyl spirohetarylindoles 3-6. The reaction of 3-chloropyridazine derivative 7 with some heterocyclic compounds having vicinal amino and cyano groups gave hetarylaminopyridazines 9 and 13. Treatment of acetylpyridazinone I with arylidenecyanoacetate and arylidenemalononitrile afforded pyridylpyridazines 16 and 19, respectively. The effect of some active methylene compounds and thioacetamide on biheterocyclic enone 22 was also studied.

  DOI：

  10.3987/com-09-11845